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10.1016/j.cell.2020.09.049 http://scihub22266oqcxt.onion/10.1016/j.cell.2020.09.049 33058755!7510528!33058755     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell 2020 ; 183 (4): 1058-1069.e19 Nephropedia Template TP {{tp|p=33058755|t=2020. A Therapeutic Non-self-reactive SARS-CoV-2 Antibody Protects from Lung Pathology in a COVID-19 Hamster Model |pdf=|usr=}}{{33058755}} gab.com Text A Therapeutic Non-self-reactive SARS-CoV-2 Antibody Protects from Lung Pathology in a COVID-19 Hamster Model JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=33058755 #FOAvip The emergence of SARS-CoV-2 led to pandemic spread of coronavirus disease 2019 (COVID-19), manifesting with respiratory symptoms and multi-organ dysfunction. Detailed characterization of virus-neutralizing antibodies and target epitopes is needed to understand COVID-19 pathophysiology and guide immunization strategies. Among 598 human monoclonal antibodies (mAbs) from 10 COVID-19 patients, we identified 40 strongly neutralizing mAbs. The most potent mAb, CV07-209, neutralized authentic SARS-CoV-2 with an IC(50) value of 3.1 ng/mL. Crystal structures of two mAbs in complex with the SARS-CoV-2 receptor-binding domain at 2.55 and 2.70 A revealed a direct block of ACE2 attachment. Interestingly, some of the near-germline SARS-CoV-2-neutralizing mAbs reacted with mammalian self-antigens. Prophylactic and therapeutic application of CV07-209 protected hamsters from SARS-CoV-2 infection, weight loss, and lung pathology. Our results show that non-self-reactive virus-neutralizing mAbs elicited during SARS-CoV-2 infection are a promising therapeutic strategy. Twit Text FOAVip A Therapeutic Non-self-reactive SARS-CoV-2 Antibody Protects from Lung Pathology in a COVID-19 Hamster Model ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=33058755 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33058755 #FOAvip English Wikipedia <ref>{{Cite pmid|33058755}}</ref> A Therapeutic Non-self-reactive SARS-CoV-2 Antibody Protects from Lung Pathology in a COVID-19 Hamster Model #MMPMID33058755 Kreye J; Reincke SM; Kornau HC; Sanchez-Sendin E; Corman VM; Liu H; Yuan M; Wu NC; Zhu X; Lee CD; Trimpert J; Holtje M; Dietert K; Stoffler L; von Wardenburg N; van Hoof S; Homeyer MA; Hoffmann J; Abdelgawad A; Gruber AD; Bertzbach LD; Vladimirova D; Li LY; Barthel PC; Skriner K; Hocke AC; Hippenstiel S; Witzenrath M; Suttorp N; Kurth F; Franke C; Endres M; Schmitz D; Jeworowski LM; Richter A; Schmidt ML; Schwarz T; Muller MA; Drosten C; Wendisch D; Sander LE; Osterrieder N; Wilson IA; Pruss H Cell 2020[Nov]; 183 (4): 1058-1069.e19 PMID33058755show ga The emergence of SARS-CoV-2 led to pandemic spread of coronavirus disease 2019 (COVID-19), manifesting with respiratory symptoms and multi-organ dysfunction. Detailed characterization of virus-neutralizing antibodies and target epitopes is needed to understand COVID-19 pathophysiology and guide immunization strategies. Among 598 human monoclonal antibodies (mAbs) from 10 COVID-19 patients, we identified 40 strongly neutralizing mAbs. The most potent mAb, CV07-209, neutralized authentic SARS-CoV-2 with an IC(50) value of 3.1 ng/mL. Crystal structures of two mAbs in complex with the SARS-CoV-2 receptor-binding domain at 2.55 and 2.70 A revealed a direct block of ACE2 attachment. Interestingly, some of the near-germline SARS-CoV-2-neutralizing mAbs reacted with mammalian self-antigens. Prophylactic and therapeutic application of CV07-209 protected hamsters from SARS-CoV-2 infection, weight loss, and lung pathology. Our results show that non-self-reactive virus-neutralizing mAbs elicited during SARS-CoV-2 infection are a promising therapeutic strategy. |Angiotensin-Converting Enzyme 2[MESH] |Animals[MESH] |Antibodies, Monoclonal/*immunology/therapeutic use[MESH] |Antibodies, Neutralizing/immunology[MESH] |Antibodies, Viral/*immunology/therapeutic use[MESH] |Antigen-Antibody Reactions[MESH] |Betacoronavirus/immunology/*metabolism/pathogenicity[MESH] |Binding Sites[MESH] |COVID-19[MESH] |Coronavirus Infections/drug therapy/*pathology/virology[MESH] |Cricetinae[MESH] |Crystallography, X-Ray[MESH] |Disease Models, Animal[MESH] |Humans[MESH] |Kinetics[MESH] |Lung/immunology/metabolism/pathology[MESH] |Mice[MESH] |Mice, Inbred C57BL[MESH] |Molecular Dynamics Simulation[MESH] |Pandemics[MESH] |Peptidyl-Dipeptidase A/chemistry/metabolism[MESH] |Pneumonia, Viral/drug therapy/*pathology/virology[MESH] |Protein Binding[MESH] |SARS-CoV-2[MESH]A Therapeutic Non-self-reactive SARS-CoV-2 Antibody Protects from Lung(epmc).pdf DeepDyve Pubget Overpricing