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10.3201/2701.203772

http://scihub22266oqcxt.onion/10.3201/2701.203772
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33058753!ä!33058753

suck abstract from ncbi


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pmid33058753      Emerg+Infect+Dis 2021 ; 27 (1): ä
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  • Cellular Immunity in COVID-19 Convalescents with PCR-Confirmed Infection but with Undetectable SARS-CoV-2-Specific IgG #MMPMID33058753
  • Schwarzkopf S; Krawczyk A; Knop D; Klump H; Heinold A; Heinemann FM; Thummler L; Temme C; Breyer M; Witzke O; Dittmer U; Lenz V; Horn PA; Lindemann M
  • Emerg Infect Dis 2021[Jan]; 27 (1): ä PMID33058753show ga
  • We investigated immune responses against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) among a group of convalescent, potential blood donors in Germany who had PCR-confirmed SARS-CoV-2 infection. Sixty days after onset of symptoms, 13/78 (17%) study participants had borderline or negative results to an ELISA detecting IgG against the S1 protein of SARS-CoV-2. We analyzed participants with PCR-confirmed infection who had strong antibody responses (ratio >3) as positive controls and participants without symptoms of SARS-CoV-2 infection and without household contact with infected patients as negative controls. Using interferon-gamma ELISpot, we observed that 78% of PCR-positive volunteers with undetectable antibodies showed T cell immunity against SARS-CoV-2. We observed a similar frequency (80%) of T-cell immunity in convalescent donors with strong antibody responses but did not detect immunity in negative controls. We concluded that, in convalescent patients with undetectable SARS-CoV-2 IgG, immunity may be mediated through T cells.
  • |*Antibody Specificity[MESH]
  • |*SARS-CoV-2[MESH]
  • |Adult[MESH]
  • |Antibodies, Viral/blood[MESH]
  • |Blood Donors[MESH]
  • |COVID-19/*immunology/virology[MESH]
  • |Enzyme-Linked Immunospot Assay/methods[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Immunity, Cellular/*physiology[MESH]
  • |Immunoglobulin G/*blood[MESH]
  • |Interferon-gamma[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Polymerase Chain Reaction[MESH]


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