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10.1111/jcmm.15883 http://scihub22266oqcxt.onion/10.1111/jcmm.15883 33058425!7686987!33058425     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Cell+Mol+Med 2020 ; 24 (21): 12869-12872 Nephropedia Template TP {{tp|p=33058425|t=2020. Cannabidiol (CBD) modulation of apelin in acute respiratory distress syndrome |pdf=|usr=}}{{33058425}} gab.com Text Cannabidiol (CBD) modulation of apelin in acute respiratory distress syndrome JO: J Cell Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=33058425 #FOAvip Considering lack of target-specific antiviral treatment and vaccination for COVID-19, it is absolutely exigent to have an effective therapeutic modality to reduce hospitalization and mortality rate as well as to improve COVID-19-infected patient outcomes. In a follow-up study to our recent findings indicating the potential of Cannabidiol (CBD) in the treatment of acute respiratory distress syndrome (ARDS), here we show for the first time that CBD may ameliorate the symptoms of ARDS through up-regulation of apelin, a peptide with significant role in the central and peripheral regulation of immunity, CNS, metabolic and cardiovascular system. By administering intranasal Poly (I:C), a synthetic viral dsRNA, while we were able to mimic the symptoms of ARDS in a murine model, interestingly, there was a significant decrease in the expression of apelin in both blood and lung tissues. CBD treatment was able to reverse the symptoms of ARDS towards a normal level. Importantly, CBD treatment increased the apelin expression significantly, suggesting a potential crosstalk between apelinergic system and CBD may be the therapeutic target in the treatment of inflammatory diseases such as COVID-19 and many other pathologic conditions. Twit Text FOAVip Cannabidiol (CBD) modulation of apelin in acute respiratory distress syndrome ????J Cell Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=33058425 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33058425 #FOAvip English Wikipedia <ref>{{Cite pmid|33058425}}</ref> Cannabidiol (CBD) modulation of apelin in acute respiratory distress syndrome #MMPMID33058425 Salles EL; Khodadadi H; Jarrahi A; Ahluwalia M; Paffaro VA Jr; Costigliola V; Yu JC; Hess DC; Dhandapani KM; Baban B J Cell Mol Med 2020[Nov]; 24 (21): 12869-12872 PMID33058425show ga Considering lack of target-specific antiviral treatment and vaccination for COVID-19, it is absolutely exigent to have an effective therapeutic modality to reduce hospitalization and mortality rate as well as to improve COVID-19-infected patient outcomes. In a follow-up study to our recent findings indicating the potential of Cannabidiol (CBD) in the treatment of acute respiratory distress syndrome (ARDS), here we show for the first time that CBD may ameliorate the symptoms of ARDS through up-regulation of apelin, a peptide with significant role in the central and peripheral regulation of immunity, CNS, metabolic and cardiovascular system. By administering intranasal Poly (I:C), a synthetic viral dsRNA, while we were able to mimic the symptoms of ARDS in a murine model, interestingly, there was a significant decrease in the expression of apelin in both blood and lung tissues. CBD treatment was able to reverse the symptoms of ARDS towards a normal level. Importantly, CBD treatment increased the apelin expression significantly, suggesting a potential crosstalk between apelinergic system and CBD may be the therapeutic target in the treatment of inflammatory diseases such as COVID-19 and many other pathologic conditions. |Administration, Intranasal[MESH] |Animals[MESH] |Apelin/*metabolism[MESH] |Cannabidiol/*pharmacology[MESH] |Lung/drug effects/pathology[MESH] |Male[MESH] |Mice, Inbred C57BL[MESH] |Poly I-C/toxicity[MESH]Cannabidiol (CBD) modulation of apelin in acute respiratory distress s(epmc).pdf DeepDyve Pubget Overpricing