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10.1128/CMR.00074-20

http://scihub22266oqcxt.onion/10.1128/CMR.00074-20
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33055229!7566897!33055229
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suck abstract from ncbi


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pmid33055229      Clin+Microbiol+Rev 2020 ; 34 (1): ä
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  • Immunopathogenesis of Coronavirus-Induced Acute Respiratory Distress Syndrome (ARDS): Potential Infection-Associated Hemophagocytic Lymphohistiocytosis #MMPMID33055229
  • Quan C; Li C; Ma H; Li Y; Zhang H
  • Clin Microbiol Rev 2020[Oct]; 34 (1): ä PMID33055229show ga
  • The outbreak of coronavirus disease 2019 (COVID-19) in December 2019 in Wuhan, China, introduced the third highly pathogenic coronavirus into humans in the 21st century. Scientific advance after the severe acute respiratory syndrome coronavirus (SARS-CoV) epidemic and Middle East respiratory syndrome coronavirus (MERS-CoV) emergence enabled clinicians to understand the epidemiology and pathophysiology of SARS-CoV-2. In this review, we summarize and discuss the epidemiology, clinical features, and virology of and host immune responses to SARS-CoV, MERS-CoV, and SARS-CoV-2 and the pathogenesis of coronavirus-induced acute respiratory distress syndrome (ARDS). We especially highlight that highly pathogenic coronaviruses might cause infection-associated hemophagocytic lymphohistiocytosis, which is involved in the immunopathogenesis of human coronavirus-induced ARDS, and also discuss the potential implication of hemophagocytic lymphohistiocytosis therapeutics for combating severe coronavirus infection.
  • |*Pandemics[MESH]
  • |Betacoronavirus/genetics/immunology/pathogenicity[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/*epidemiology/immunology/mortality/physiopathology[MESH]
  • |Cytokine Release Syndrome/*epidemiology/immunology/mortality/physiopathology[MESH]
  • |Host-Pathogen Interactions[MESH]
  • |Humans[MESH]
  • |Infectious Disease Incubation Period[MESH]
  • |Lung/immunology/physiopathology/virology[MESH]
  • |Lymphohistiocytosis, Hemophagocytic/*epidemiology/immunology/mortality/physiopathology[MESH]
  • |Middle East Respiratory Syndrome Coronavirus/genetics/immunology/pathogenicity[MESH]
  • |Phylogeny[MESH]
  • |Pneumonia, Viral/*epidemiology/immunology/mortality/physiopathology[MESH]
  • |SARS-CoV-2[MESH]
  • |Severe Acute Respiratory Syndrome/*epidemiology/immunology/mortality/physiopathology[MESH]
  • |Severe acute respiratory syndrome-related coronavirus/genetics/immunology/pathogenicity[MESH]
  • |Severity of Illness Index[MESH]


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