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10.1186/s10020-020-00223-w http://scihub22266oqcxt.onion/10.1186/s10020-020-00223-w 33054759!7556585!33054759     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mol+Med 2020 ; 26 (1): 95 Nephropedia Template TP {{tp|p=33054759|t=2020. Alveolar cells under mechanical stressed niche: critical contributors to pulmonary fibrosis |pdf=|usr=}}{{33054759}} gab.com Text Alveolar cells under mechanical stressed niche: critical contributors to pulmonary fibrosis JO: Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=33054759 #FOAvip Pulmonary fibrosis arises from the repeated epithelial mild injuries and insufficient repair lead to over activation of fibroblasts and excessive deposition of extracellular matrix, which result in a mechanical stretched niche. However, increasing mechanical stress likely exists before the establishment of fibrosis since early micro injuries increase local vascular permeability and prompt cytoskeletal remodeling which alter cellular mechanical forces. It is noteworthy that COVID-19 patients with severe hypoxemia will receive mechanical ventilation as supportive treatment and subsequent pathology studies indicate lung fibrosis pattern. At advanced stages, mechanical stress originates mainly from the stiff matrix since boundaries between stiff and compliant parts of the tissue could generate mechanical stress. Therefore, mechanical stress has a significant role in the whole development process of pulmonary fibrosis. The alveoli are covered by abundant capillaries and function as the main gas exchange unit. Constantly subject to variety of damages, the alveolar epithelium injuries were recently recognized to play a vital role in the onset and development of idiopathic pulmonary fibrosis. In this review, we summarize the literature regarding the effects of mechanical stress on the fundamental cells constituting the alveoli in the process of pulmonary fibrosis, particularly on epithelial cells, capillary endothelial cells, fibroblasts, mast cells, macrophages and stem cells. Finally, we briefly review this issue from a more comprehensive perspective: the metabolic and epigenetic regulation. Twit Text FOAVip Alveolar cells under mechanical stressed niche: critical contributors to pulmonary fibrosis ????Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=33054759 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33054759 #FOAvip English Wikipedia <ref>{{Cite pmid|33054759}}</ref> Alveolar cells under mechanical stressed niche: critical contributors to pulmonary fibrosis #MMPMID33054759 Yang J; Pan X; Wang L; Yu G Mol Med 2020[Oct]; 26 (1): 95 PMID33054759show ga Pulmonary fibrosis arises from the repeated epithelial mild injuries and insufficient repair lead to over activation of fibroblasts and excessive deposition of extracellular matrix, which result in a mechanical stretched niche. However, increasing mechanical stress likely exists before the establishment of fibrosis since early micro injuries increase local vascular permeability and prompt cytoskeletal remodeling which alter cellular mechanical forces. It is noteworthy that COVID-19 patients with severe hypoxemia will receive mechanical ventilation as supportive treatment and subsequent pathology studies indicate lung fibrosis pattern. At advanced stages, mechanical stress originates mainly from the stiff matrix since boundaries between stiff and compliant parts of the tissue could generate mechanical stress. Therefore, mechanical stress has a significant role in the whole development process of pulmonary fibrosis. The alveoli are covered by abundant capillaries and function as the main gas exchange unit. Constantly subject to variety of damages, the alveolar epithelium injuries were recently recognized to play a vital role in the onset and development of idiopathic pulmonary fibrosis. In this review, we summarize the literature regarding the effects of mechanical stress on the fundamental cells constituting the alveoli in the process of pulmonary fibrosis, particularly on epithelial cells, capillary endothelial cells, fibroblasts, mast cells, macrophages and stem cells. Finally, we briefly review this issue from a more comprehensive perspective: the metabolic and epigenetic regulation. |Alveolar Epithelial Cells/immunology/pathology[MESH] |Betacoronavirus/immunology/pathogenicity[MESH] |Biomechanical Phenomena[MESH] |COVID-19[MESH] |Coronavirus Infections/genetics/*immunology/pathology/virology[MESH] |Cytokines/genetics/immunology[MESH] |Endothelial Cells/immunology/pathology[MESH] |Epigenesis, Genetic/*immunology[MESH] |Fibroblasts/immunology/pathology[MESH] |Humans[MESH] |Idiopathic Pulmonary Fibrosis/genetics/*immunology/pathology/virology[MESH] |Lung/blood supply/immunology/pathology[MESH] |Macrophages/immunology/pathology[MESH] |Mechanotransduction, Cellular/genetics/*immunology[MESH] |Pandemics[MESH] |Pneumonia, Viral/genetics/*immunology/pathology/virology[MESH] |Pulmonary Embolism/genetics/*immunology/pathology/virology[MESH] |Respiratory Insufficiency/genetics/*immunology/pathology/virology[MESH] |SARS-CoV-2[MESH]Alveolar cells under mechanical stressed niche: critical contributors (epmc).pdf DeepDyve Pubget Overpricing