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10.3390/jcm9103263

http://scihub22266oqcxt.onion/10.3390/jcm9103263
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suck abstract from ncbi


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pmid33053826      J+Clin+Med 2020 ; 9 (10): ä
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  • Redefining the Prognostic Value of High-Sensitivity Troponin in COVID-19 Patients: The Importance of Concomitant Coronary Artery Disease #MMPMID33053826
  • Schiavone M; Gasperetti A; Mancone M; Kaplan AV; Gobbi C; Mascioli G; Busana M; Saguner AM; Mitacchione G; Giacomelli A; Sardella G; Viecca M; Duru F; Antinori S; Carugo S; Bartorelli AL; Tondo C; Galli M; Fedele F; Forleo GB
  • J Clin Med 2020[Oct]; 9 (10): ä PMID33053826show ga
  • BACKGROUND: Although studies assessing cardiovascular comorbidities and myocardial injury in Coronavirus disease 2019 (COVID-19) patients have been published, no reports focused on clinical outcomes of myocardial injury in patients with and without chronic coronary syndromes (CCS) are currently available. METHODS: In this study, consecutive COVID-19 patients admitted to four different institutions were screened for enrolment. Patients were divided into two groups (CCS vs. no-CCS). Association with in-hospital mortality and related predictors represented the main study outcome; myocardial injury and its predictors were deemed secondary outcomes. RESULTS: A total of 674 COVID-19 patients were enrolled, 112 (16.6%) with an established history of CCS. Myocardial injury occurred in 43.8% patients with CCS vs. 14.4% patients without CCS, as confirmed by high-sensitivity cardiac troponin (hs-cTn) elevation on admission or during hospitalization. The mortality rate in the CCS cohort was nearly three-fold higher. After adjusting for disease severity, myocardial injury resulted significantly associated with in-hospital mortality in the no-CCS group but not in CCS patients. CONCLUSIONS: Patients with CCS and COVID-19 showed high mortality rate. Myocardial injury may be a bystander in CCS patients and COVID-19, while in patients without known history of CCS, myocardial injury has a significant role in predicting poor outcomes.
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