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10.1093/femspd/ftaa064

http://scihub22266oqcxt.onion/10.1093/femspd/ftaa064
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33053181!7665504!33053181
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suck abstract from ncbi


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pmid33053181      Pathog+Dis 2021 ; 79 (1): ä
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  • SARS-CoV-2 RT-PCR profile in 298 Indian COVID-19 patients: a retrospective observational study #MMPMID33053181
  • Bhattacharya B; Kumar R; Meena VP; Soneja M; Singh A; Das R; Xess A; Arif N; Vig S; Rastogi V; Tiwari P; Bhatnagar S; Mohan A; Wig N; Dar L
  • Pathog Dis 2021[Jan]; 79 (1): ä PMID33053181show ga
  • BACKGROUND: despite being in the 5th month of pandemic, knowledge with respect to viral dynamics, infectivity and RT-PCR positivity continues to evolve. AIM: to analyse the SARS CoV-2 nucleic acid RT-PCR profiles in COVID-19 patients. DESIGN: it was a retrospective, observational study conducted at COVID facilities under AIIMS, New Delhi. METHODS: patients admitted with laboratory confirmed COVID-19 were eligible for enrolment. Patients with incomplete details, or only single PCR tests were excluded. Data regarding demographic details, comorbidities, treatment received and results of SARS-CoV-2 RT-PCR performed on nasopharyngeal and oropharyngeal swabs, collected at different time points, was retrieved from the hospital records. RESULTS: a total of 298 patients were included, majority were males (75.8%) with mean age of 39.07 years (0.6-88 years). The mean duration from symptom onset to first positive RT-PCR was 4.7 days (SD 3.67), while that of symptom onset to last positive test was 17.83 days (SD 6.22). Proportions of positive RT-PCR tests were 100%, 49%, 24%, 8.7% and 20.6% in the 1st, 2nd, 3rd, 4th and >4 weeks of illness. A total of 12 symptomatic patients had prolonged positive test results even after 3 weeks of symptom onset. Age > = 60 years was associated with prolonged RT-PCR positivity (statistically significant). CONCLUSION: this study showed that the average period of PCR positivity is more than 2 weeks in COVID-19 patients; elderly patients have prolonged duration of RT-PCR positivity and requires further follow up.
  • |Adolescent[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |Asymptomatic Diseases[MESH]
  • |COVID-19 Nucleic Acid Testing/methods[MESH]
  • |COVID-19/*diagnosis/epidemiology/pathology/virology[MESH]
  • |Child[MESH]
  • |Child, Preschool[MESH]
  • |Comorbidity[MESH]
  • |Diabetes Mellitus/*diagnosis/epidemiology/pathology/virology[MESH]
  • |Humans[MESH]
  • |Hypertension/*diagnosis/epidemiology/pathology/virology[MESH]
  • |India/epidemiology[MESH]
  • |Infant[MESH]
  • |Infectious Disease Incubation Period[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Nasopharynx/virology[MESH]
  • |Oropharynx/virology[MESH]
  • |RNA, Viral/*genetics[MESH]
  • |Retrospective Studies[MESH]
  • |Reverse Transcriptase Polymerase Chain Reaction[MESH]
  • |SARS-CoV-2/genetics/*pathogenicity[MESH]


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