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10.1016/j.cplett.2020.138068

http://scihub22266oqcxt.onion/10.1016/j.cplett.2020.138068
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suck abstract from ncbi


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pmid33052144      Chem+Phys+Lett 2020 ; 761 (ä): 138068
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  • Identification of potential inhibitors of SARS-CoV-2 papain-like protease from tropane alkaloids from Schizanthus porrigens: A molecular docking study #MMPMID33052144
  • Alfaro M; Alfaro I; Angel C
  • Chem Phys Lett 2020[Dec]; 761 (ä): 138068 PMID33052144show ga
  • This paper presents identification of potential inhibitors of SARS-CoV-2 papain-like protease from tropane alkaloids from Schizanthus porrigens, using molecular docking method. Binding affinities were compared with those obtained with Lopinavir as a SARS-CoV-2 papain-like protease inhibitor. Overall, our findings indicate that Schizanthine Z binds to the SARS-CoV-2 papain-like protease with relatively high affinity and favorable ADME properties. Therefore, Schizanthine Z may represent an appropriate compound for further evaluation in antiviral assays.
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