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10.1038/s41598-020-74328-x

http://scihub22266oqcxt.onion/10.1038/s41598-020-74328-x
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33051534!7555891!33051534
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suck abstract from ncbi


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pmid33051534      Sci+Rep 2020 ; 10 (1): 17100
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  • Lack of tocilizumab effect on mortality in COVID19 patients #MMPMID33051534
  • Holt GE; Batra M; Murthi M; Kambali S; Santos K; Bastidas MVP; Asif H; Haddadi S; Arias S; Mirsaeidi M
  • Sci Rep 2020[Oct]; 10 (1): 17100 PMID33051534show ga
  • Off-label tocilizumab use in COVID-19 patients reflects concern for cytokine release syndrome. Comparison of matched COVID-19 pneumonia patients found elevated IL-6 levels correlated with mortality that did not change with tocilizumab administration. Correlating mortality with increased IL-6 doesn't imply causality however lack of improvement by tocilizumab requires further clinical trial alterations.
  • |Adult[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |Antibodies, Monoclonal, Humanized/immunology/*therapeutic use[MESH]
  • |Betacoronavirus/isolation & purification[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/*drug therapy/mortality/virology[MESH]
  • |Female[MESH]
  • |Ferritins/analysis[MESH]
  • |Humans[MESH]
  • |Interleukin-6/analysis[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Odds Ratio[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*drug therapy/mortality/virology[MESH]
  • |Proportional Hazards Models[MESH]
  • |Receptors, Interleukin-6/immunology[MESH]
  • |SARS-CoV-2[MESH]


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