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10.7554/eLife.58107 http://scihub22266oqcxt.onion/10.7554/eLife.58107 33051002!7655102!33051002     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33051002&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Elife 2020 ; 9 (?): ? Nephropedia Template TP {{tp|p=33051002|t=2020. Cytoplasmic sharing through apical membrane remodeling |pdf=|usr=}}{{33051002}} gab.com Text Cytoplasmic sharing through apical membrane remodeling JO: Elife http://www.kidney.de/pget.php?&tw=1&pmid=33051002 #FOAvip Multiple nuclei sharing a common cytoplasm are found in diverse tissues, organisms, and diseases. Yet, multinucleation remains a poorly understood biological property. Cytoplasm sharing invariably involves plasma membrane breaches. In contrast, we discovered cytoplasm sharing without membrane breaching in highly resorptive Drosophila rectal papillae. During a six-hour developmental window, 100 individual papillar cells assemble a multinucleate cytoplasm, allowing passage of proteins of at least 62 kDa throughout papillar tissue. Papillar cytoplasm sharing does not employ canonical mechanisms such as incomplete cytokinesis or muscle fusion pore regulators. Instead, sharing requires gap junction proteins (normally associated with transport of molecules < 1 kDa), which are positioned by membrane remodeling GTPases. Our work reveals a new role for apical membrane remodeling in converting a multicellular epithelium into a giant multinucleate cytoplasm. Twit Text FOAVip Cytoplasmic sharing through apical membrane remodeling ????Elife http://www.kidney.de/pget.php?&tw=1&pmid=33051002 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33051002 #FOAvip English Wikipedia <ref>{{Cite pmid|33051002}}</ref> Cytoplasmic sharing through apical membrane remodeling #MMPMID33051002 Peterson NG; Stormo BM; Schoenfelder KP; King JS; Lee RR; Fox DT Elife 2020[Oct]; 9 (?): ? PMID33051002show ga Multiple nuclei sharing a common cytoplasm are found in diverse tissues, organisms, and diseases. Yet, multinucleation remains a poorly understood biological property. Cytoplasm sharing invariably involves plasma membrane breaches. In contrast, we discovered cytoplasm sharing without membrane breaching in highly resorptive Drosophila rectal papillae. During a six-hour developmental window, 100 individual papillar cells assemble a multinucleate cytoplasm, allowing passage of proteins of at least 62 kDa throughout papillar tissue. Papillar cytoplasm sharing does not employ canonical mechanisms such as incomplete cytokinesis or muscle fusion pore regulators. Instead, sharing requires gap junction proteins (normally associated with transport of molecules < 1 kDa), which are positioned by membrane remodeling GTPases. Our work reveals a new role for apical membrane remodeling in converting a multicellular epithelium into a giant multinucleate cytoplasm. |Animals[MESH] |Cell Membrane/*metabolism[MESH] |Connexins/metabolism[MESH] |Crosses, Genetic[MESH] |Cytokinesis[MESH] |Cytoplasm/*metabolism[MESH] |Cytosol/metabolism[MESH] |Drosophila melanogaster/*embryology[MESH] |Epithelium/metabolism[MESH] |GTP Phosphohydrolases/chemistry[MESH] |Gap Junctions[MESH] |Genotype[MESH] |Intestines/*embryology[MESH] |Microscopy, Electron, Transmission[MESH]Cytoplasmic sharing through apical membrane remodeling (epmc).pdf DeepDyve Pubget Overpricing