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10.1098/rsob.200161 http://scihub22266oqcxt.onion/10.1098/rsob.200161 33050789!7653352!33050789     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Open+Biol 2020 ; 10 (10): 200161 Nephropedia Template TP {{tp|p=33050789|t=2020. Endothelial cells, neutrophils and platelets: getting to the bottom of an inflammatory triangle |pdf=|usr=}}{{33050789}} gab.com Text Endothelial cells, neutrophils and platelets: getting to the bottom of an inflammatory triangle JO: Open Biol http://www.kidney.de/pget.php?&tw=1&pmid=33050789 #FOAvip Severe fibrotic and thrombotic events permeate the healthcare system, causing suffering for millions of patients with inflammatory disorders. As late-state consequences of chronic inflammation, fibrosis and thrombosis are the culmination of pathological interactions of activated endothelium, neutrophils and platelets after vessel injury. Coupling of these three cell types ensures a pro-coagulant, cytokine-rich environment that promotes the capture, activation and proliferation of circulating immune cells and recruitment of key pro-fibrotic cell types such as myofibroblasts. As the first responders to sterile inflammatory injury, it is important to understand how endothelial cells, neutrophils and platelets help create this environment. There has been a growing interest in this intersection over the past decade that has helped shape the development of therapeutics to target these processes. Here, we review recent insights into how neutrophils, platelets and endothelial cells guide the development of pathological vessel repair that can also result in underlying tissue fibrosis. We further discuss recent efforts that have been made to translate this knowledge into therapeutics and provide perspective as to how a compound or combination therapeutics may be most efficacious when tackling fibrosis and thrombosis that is brought upon by chronic inflammation. Twit Text FOAVip Endothelial cells, neutrophils and platelets: getting to the bottom of an inflammatory triangle ????Open Biol http://www.kidney.de/pget.php?&tw=1&pmid=33050789 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33050789 #FOAvip English Wikipedia <ref>{{Cite pmid|33050789}}</ref> Endothelial cells, neutrophils and platelets: getting to the bottom of an inflammatory triangle #MMPMID33050789 Dehghani T; Panitch A Open Biol 2020[Oct]; 10 (10): 200161 PMID33050789show ga Severe fibrotic and thrombotic events permeate the healthcare system, causing suffering for millions of patients with inflammatory disorders. As late-state consequences of chronic inflammation, fibrosis and thrombosis are the culmination of pathological interactions of activated endothelium, neutrophils and platelets after vessel injury. Coupling of these three cell types ensures a pro-coagulant, cytokine-rich environment that promotes the capture, activation and proliferation of circulating immune cells and recruitment of key pro-fibrotic cell types such as myofibroblasts. As the first responders to sterile inflammatory injury, it is important to understand how endothelial cells, neutrophils and platelets help create this environment. There has been a growing interest in this intersection over the past decade that has helped shape the development of therapeutics to target these processes. Here, we review recent insights into how neutrophils, platelets and endothelial cells guide the development of pathological vessel repair that can also result in underlying tissue fibrosis. We further discuss recent efforts that have been made to translate this knowledge into therapeutics and provide perspective as to how a compound or combination therapeutics may be most efficacious when tackling fibrosis and thrombosis that is brought upon by chronic inflammation. |*Disease Susceptibility[MESH] |Animals[MESH] |Biomarkers[MESH] |Blood Platelets/*metabolism[MESH] |Cell Adhesion/genetics/immunology[MESH] |Disease Management[MESH] |Endothelial Cells/*metabolism[MESH] |Fibrosis[MESH] |Humans[MESH] |Inflammation/*etiology/*metabolism/pathology/therapy[MESH] |Neutrophils/immunology/*metabolism[MESH] |Platelet Aggregation[MESH]Endothelial cells, neutrophils and platelets: getting to the bottom of(epmc).pdf DeepDyve Pubget Overpricing