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10.3390/molecules25204597 http://scihub22266oqcxt.onion/10.3390/molecules25204597 33050240!7594251!33050240     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33050240&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Molecules 2020 ; 25 (20): ? Nephropedia Template TP {{tp|p=33050240|t=2020. NMR as a "Gold Standard" Method in Drug Design and Discovery |pdf=|usr=}}{{33050240}} gab.com Text NMR as a "Gold Standard" Method in Drug Design and Discovery JO: Molecules http://www.kidney.de/pget.php?&tw=1&pmid=33050240 #FOAvip Studying disease models at the molecular level is vital for drug development in order to improve treatment and prevent a wide range of human pathologies. Microbial infections are still a major challenge because pathogens rapidly and continually evolve developing drug resistance. Cancer cells also change genetically, and current therapeutic techniques may be (or may become) ineffective in many cases. The pathology of many neurological diseases remains an enigma, and the exact etiology and underlying mechanisms are still largely unknown. Viral infections spread and develop much more quickly than does the corresponding research needed to prevent and combat these infections; the present and most relevant outbreak of SARS-CoV-2, which originated in Wuhan, China, illustrates the critical and immediate need to improve drug design and development techniques. Modern day drug discovery is a time-consuming, expensive process. Each new drug takes in excess of 10 years to develop and costs on average more than a billion US dollars. This demonstrates the need of a complete redesign or novel strategies. Nuclear Magnetic Resonance (NMR) has played a critical role in drug discovery ever since its introduction several decades ago. In just three decades, NMR has become a "gold standard" platform technology in medical and pharmacology studies. In this review, we present the major applications of NMR spectroscopy in medical drug discovery and development. The basic concepts, theories, and applications of the most commonly used NMR techniques are presented. We also summarize the advantages and limitations of the primary NMR methods in drug development. Twit Text FOAVip NMR as a "Gold Standard" Method in Drug Design and Discovery ????Molecules http://www.kidney.de/pget.php?&tw=1&pmid=33050240 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33050240 #FOAvip English Wikipedia <ref>{{Cite pmid|33050240}}</ref> NMR as a "Gold Standard" Method in Drug Design and Discovery #MMPMID33050240 Emwas AH; Szczepski K; Poulson BG; Chandra K; McKay RT; Dhahri M; Alahmari F; Jaremko L; Lachowicz JI; Jaremko M Molecules 2020[Oct]; 25 (20): ? PMID33050240show ga Studying disease models at the molecular level is vital for drug development in order to improve treatment and prevent a wide range of human pathologies. Microbial infections are still a major challenge because pathogens rapidly and continually evolve developing drug resistance. Cancer cells also change genetically, and current therapeutic techniques may be (or may become) ineffective in many cases. The pathology of many neurological diseases remains an enigma, and the exact etiology and underlying mechanisms are still largely unknown. Viral infections spread and develop much more quickly than does the corresponding research needed to prevent and combat these infections; the present and most relevant outbreak of SARS-CoV-2, which originated in Wuhan, China, illustrates the critical and immediate need to improve drug design and development techniques. Modern day drug discovery is a time-consuming, expensive process. Each new drug takes in excess of 10 years to develop and costs on average more than a billion US dollars. This demonstrates the need of a complete redesign or novel strategies. Nuclear Magnetic Resonance (NMR) has played a critical role in drug discovery ever since its introduction several decades ago. In just three decades, NMR has become a "gold standard" platform technology in medical and pharmacology studies. In this review, we present the major applications of NMR spectroscopy in medical drug discovery and development. The basic concepts, theories, and applications of the most commonly used NMR techniques are presented. We also summarize the advantages and limitations of the primary NMR methods in drug development. |*Drug Design[MESH] |Drug Discovery/*methods[MESH] |Humans[MESH]NMR as a "Gold Standard" Method in Drug Design and Discovery (epmc).pdf DeepDyve Pubget Overpricing