Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1016/j.biopha.2020.110816 http://scihub22266oqcxt.onion/10.1016/j.biopha.2020.110816 33049583!7547400!33049583     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biomed+Pharmacother 2020 ; 132 (ä): 110816 Nephropedia Template TP {{tp|p=33049583|t=2020. GB-2 inhibits ACE2 and TMPRSS2 expression: In vivo and in vitro studies |pdf=|usr=}}{{33049583}} gab.com Text GB-2 inhibits ACE2 and TMPRSS2 expression: In vivo and in vitro studies JO: Biomed Pharmacother http://www.kidney.de/pget.php?&tw=1&pmid=33049583 #FOAvip After the first case of Coronavirus disease 2019 (COVID-19) was reported in Wuhan, COVID-19 has rapidly spread to almost all parts of world. Angiotensin converting enzyme 2 (ACE2) receptor can bind to spike protein of SARS-CoV-2. Then, the spike protein of SARS-CoV-2 can be cleaved and activated by transmembrane protease, serine 2 (TMPRSS2) of the host cells for SARS-CoV-2 infection. Therefore, ACE2 and TMPRSS2 are potential antiviral targets for treatment of prevention of SARS-CoV-2 infection. In this study, we discovered that 10-250 mug/mL of GB-2, from Tian Shang Sheng Mu of Chiayi Puzi Peitian Temple, can inhibit ACE2 mRNA expression and ACE2 and TMPRSS2 protein expression in HepG2 and 293 T cells without cytotoxicity. GB-2 treatment could decrease ACE2 and TMPRSS2 expression level of lung tissue and kidney tissue without adverse effects, including nephrotoxicity and hepatotoxicity, in animal model. In the compositions of GB-2, we discovered that 50 mug/mL of theaflavin could inhibit protein expression of ACE2 and TMPRSS2. Theaflavin could inhibit the mRNA expression of ACE2. In conclusion, our results suggest that GB-2 and theaflavin could act as potential compounds for ACE2 and TMPRSS2 inhibitors in the further clinical study. Twit Text FOAVip GB-2 inhibits ACE2 and TMPRSS2 expression: In vivo and in vitro studies ????Biomed Pharmacother http://www.kidney.de/pget.php?&tw=1&pmid=33049583 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33049583 #FOAvip English Wikipedia <ref>{{Cite pmid|33049583}}</ref> GB-2 inhibits ACE2 and TMPRSS2 expression: In vivo and in vitro studies #MMPMID33049583 Wu CY; Lin YS; Yang YH; Shu LH; Cheng YC; Liu HT Biomed Pharmacother 2020[Dec]; 132 (ä): 110816 PMID33049583show ga After the first case of Coronavirus disease 2019 (COVID-19) was reported in Wuhan, COVID-19 has rapidly spread to almost all parts of world. Angiotensin converting enzyme 2 (ACE2) receptor can bind to spike protein of SARS-CoV-2. Then, the spike protein of SARS-CoV-2 can be cleaved and activated by transmembrane protease, serine 2 (TMPRSS2) of the host cells for SARS-CoV-2 infection. Therefore, ACE2 and TMPRSS2 are potential antiviral targets for treatment of prevention of SARS-CoV-2 infection. In this study, we discovered that 10-250 mug/mL of GB-2, from Tian Shang Sheng Mu of Chiayi Puzi Peitian Temple, can inhibit ACE2 mRNA expression and ACE2 and TMPRSS2 protein expression in HepG2 and 293 T cells without cytotoxicity. GB-2 treatment could decrease ACE2 and TMPRSS2 expression level of lung tissue and kidney tissue without adverse effects, including nephrotoxicity and hepatotoxicity, in animal model. In the compositions of GB-2, we discovered that 50 mug/mL of theaflavin could inhibit protein expression of ACE2 and TMPRSS2. Theaflavin could inhibit the mRNA expression of ACE2. In conclusion, our results suggest that GB-2 and theaflavin could act as potential compounds for ACE2 and TMPRSS2 inhibitors in the further clinical study. |Angiotensin-Converting Enzyme 2/*biosynthesis/genetics[MESH] |Angiotensin-Converting Enzyme Inhibitors/isolation & purification/pharmacology/therapeutic use[MESH] |Animals[MESH] |COVID-19 Drug Treatment[MESH] |COVID-19/epidemiology[MESH] |Drugs, Chinese Herbal/isolation & purification/*pharmacology/therapeutic use[MESH] |Gene Expression/drug effects[MESH] |HEK293 Cells[MESH] |Hep G2 Cells[MESH] |Humans[MESH] |Male[MESH] |Mice[MESH] |Mice, Inbred C57BL[MESH] |Protease Inhibitors/isolation & purification/pharmacology/therapeutic use[MESH] |SARS-CoV-2[MESH]GB-2 inhibits ACE2 and TMPRSS2 expression: In vivo and in vitro studie(epmc).pdf DeepDyve Pubget Overpricing