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10.1016/j.jinf.2020.10.009

http://scihub22266oqcxt.onion/10.1016/j.jinf.2020.10.009
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suck abstract from ncbi


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pmid33049331      J+Infect 2020 ; 81 (6): 847-856
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  • The duration of infectiousness of individuals infected with SARS-CoV-2 #MMPMID33049331
  • Walsh KA; Spillane S; Comber L; Cardwell K; Harrington P; Connell J; Teljeur C; Broderick N; de Gascun CF; Smith SM; Ryan M; O'Neill M
  • J Infect 2020[Dec]; 81 (6): 847-856 PMID33049331show ga
  • OBJECTIVES: To summarise the evidence on the duration of infectiousness of individuals in whom SARS-CoV-2 ribonucleic acid is detected. METHODS: A rapid review was undertaken in PubMed, Europe PubMed Central and EMBASE from 1 January 2020 to 26 August 2020. RESULTS: We identified 15 relevant studies, including 13 virus culture and 2 contact tracing studies. For 5 virus culture studies, the last day on which SARS-CoV-2 was isolated occurred within 10 days of symptom onset. For another 5 studies, SARS-CoV-2 was isolated beyond day 10 for approximately 3% of included patients. The remaining 3 virus culture studies included patients with severe or critical disease; SARS-CoV-2 was isolated up to day 32 in one study. Two studies identified immunocompromised patients from whom SARS-CoV-2 was isolated for up to 20 days. Both contact tracing studies, when close contacts were first exposed greater than 5 days after symptom onset in the index case, found no evidence of laboratory-confirmed onward transmission of SARS-CoV-2. CONCLUSION: COVID-19 patients with mild-to-moderate illness are highly unlikely to be infectious beyond 10 days of symptoms. However, evidence from a limited number of studies indicates that patients with severe-to-critical illness or who are immunocompromised, may shed infectious virus for longer.
  • |COVID-19/*epidemiology/genetics/*transmission[MESH]
  • |Contact Tracing[MESH]
  • |Disease Transmission, Infectious/*statistics & numerical data[MESH]
  • |Humans[MESH]
  • |Patient Isolation[MESH]
  • |RNA, Viral/*isolation & purification[MESH]
  • |Reverse Transcriptase Polymerase Chain Reaction[MESH]
  • |SARS-CoV-2/*isolation & purification[MESH]
  • |Severity of Illness Index[MESH]
  • |Time Factors[MESH]


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