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10.1167/iovs.61.12.13 http://scihub22266oqcxt.onion/10.1167/iovs.61.12.13 33049061!7571327!33049061     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Invest+Ophthalmol+Vis+Sci 2020 ; 61 (12): 13 Nephropedia Template TP {{tp|p=33049061|t=2020. Co-Expression of Mitochondrial Genes and ACE2 in Cornea Involved in COVID-19 |pdf=|usr=}}{{33049061}} gab.com Text Co-Expression of Mitochondrial Genes and ACE2 in Cornea Involved in COVID-19 JO: Invest Ophthalmol Vis Sci http://www.kidney.de/pget.php?&tw=1&pmid=33049061 #FOAvip PURPOSE: The coronavirus disease 2019 (COVID-19) pandemic severely challenges public health and necessitates the need for increasing our understanding of COVID-19 pathogenesis, especially host factors facilitating virus infection and propagation. The aim of this study was to investigate key factors for cellular susceptibility to severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) infection in the ocular surface cells. METHODS: We combined co-expression and SARS-CoV-2 interactome network to predict key genes at COVID-19 in ocular infection based on the premise that genes underlying a disease are often functionally related and functionally related genes are often co-expressed. RESULTS: The co-expression network was constructed by mapping the well-known angiotensin converting enzyme (ACE2), TMPRSS2, and host susceptibility genes implicated in COVID-19 genomewide association study (GWAS) onto a cornea, retinal pigment epithelium, and lung. We found a significant co-expression module of these genes in the cornea, revealing that cornea is potential extra-respiratory entry portal of SARS-CoV-2. Strikingly, both co-expression and interaction networks show a significant enrichment in mitochondrial function, which are the hub of cellular oxidative homeostasis, inflammation, and innate immune response. We identified a corneal mitochondrial susceptibility module (CMSM) of 14 mitochondrial genes by integrating ACE2 co-expression cluster and SARS-CoV-2 interactome. The gene ECSIT, as a cytosolic adaptor protein involved in inflammatory responses, exhibits the strongest correlation with ACE2 in CMSM, which has shown to be an important risk factor for SARS-CoV-2 infection and prognosis. CONCLUSIONS: Our co-expression and protein interaction network analysis uncover that the mitochondrial function related genes in cornea contribute to the dissection of COVID-19 susceptibility and potential therapeutic interventions. Twit Text FOAVip Co-Expression of Mitochondrial Genes and ACE2 in Cornea Involved in COVID-19 ????Invest Ophthalmol Vis Sci http://www.kidney.de/pget.php?&tw=1&pmid=33049061 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33049061 #FOAvip English Wikipedia <ref>{{Cite pmid|33049061}}</ref> Co-Expression of Mitochondrial Genes and ACE2 in Cornea Involved in COVID-19 #MMPMID33049061 Yuan J; Fan D; Xue Z; Qu J; Su J Invest Ophthalmol Vis Sci 2020[Oct]; 61 (12): 13 PMID33049061show ga PURPOSE: The coronavirus disease 2019 (COVID-19) pandemic severely challenges public health and necessitates the need for increasing our understanding of COVID-19 pathogenesis, especially host factors facilitating virus infection and propagation. The aim of this study was to investigate key factors for cellular susceptibility to severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) infection in the ocular surface cells. METHODS: We combined co-expression and SARS-CoV-2 interactome network to predict key genes at COVID-19 in ocular infection based on the premise that genes underlying a disease are often functionally related and functionally related genes are often co-expressed. RESULTS: The co-expression network was constructed by mapping the well-known angiotensin converting enzyme (ACE2), TMPRSS2, and host susceptibility genes implicated in COVID-19 genomewide association study (GWAS) onto a cornea, retinal pigment epithelium, and lung. We found a significant co-expression module of these genes in the cornea, revealing that cornea is potential extra-respiratory entry portal of SARS-CoV-2. Strikingly, both co-expression and interaction networks show a significant enrichment in mitochondrial function, which are the hub of cellular oxidative homeostasis, inflammation, and innate immune response. We identified a corneal mitochondrial susceptibility module (CMSM) of 14 mitochondrial genes by integrating ACE2 co-expression cluster and SARS-CoV-2 interactome. The gene ECSIT, as a cytosolic adaptor protein involved in inflammatory responses, exhibits the strongest correlation with ACE2 in CMSM, which has shown to be an important risk factor for SARS-CoV-2 infection and prognosis. CONCLUSIONS: Our co-expression and protein interaction network analysis uncover that the mitochondrial function related genes in cornea contribute to the dissection of COVID-19 susceptibility and potential therapeutic interventions. |*Betacoronavirus[MESH] |*Gene Expression Regulation[MESH] |COVID-19[MESH] |Cell Line[MESH] |Cornea/*metabolism/pathology[MESH] |Coronavirus Infections/epidemiology/*genetics/metabolism[MESH] |Genes, Mitochondrial/*genetics[MESH] |Humans[MESH] |Pandemics[MESH] |Peptidyl-Dipeptidase A/biosynthesis/*genetics[MESH] |Pneumonia, Viral/epidemiology/*genetics/metabolism[MESH] |RNA/*genetics[MESH]Co-Expression of Mitochondrial Genes and ACE2 in Cornea Involved in CO(epmc).pdf DeepDyve Pubget Overpricing