Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1002/iid3.358 http://scihub22266oqcxt.onion/10.1002/iid3.358 33047883!7654404!33047883     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Immun+Inflamm+Dis 2020 ; 8 (4): 684-694 Nephropedia Template TP {{tp|p=33047883|t=2020. Association between HLA gene polymorphisms and mortality of COVID-19: An in silico analysis |pdf=|usr=}}{{33047883}} gab.com Text Association between HLA gene polymorphisms and mortality of COVID-19: An in silico analysis JO: Immun Inflamm Dis http://www.kidney.de/pget.php?&tw=1&pmid=33047883 #FOAvip INTRODUCTION: The emergence of SARS-CoV-2 has caused global public health and economic crisis. Human leukocyte antigen (HLA) is a critical component of the viral antigen presentation pathway and plays essential roles in conferring differential viral susceptibility and severity of diseases. However, the association between HLA gene polymorphisms and risk for COVID-19 has not been fully elucidated. We hypothesized that HLA genotypes might impact on the differences in morbidity and mortality of COVID-19 across countries. METHODS: We conducted in silico analyses and examined an association of HLA gene polymorphisms with prevalence and mortality of COVID-19 by using publicly available databases. RESULTS: We found that a possible association between HLA-A*02:01 and an increased risk for COVID-19. HLA-A*02:01 had a relatively lower capacity to present SARS-CoV-2 antigens compared with other frequent HLA class I molecules, HLA-A*11:01 or HLA-A*24:02. CONCLUSION: This study suggests that individuals with HLA-A*11:01 or HLA-A*24:02 genotypes may generate efficiently T-cell-mediated antiviral responses to SARS-CoV-2 compared with HLA-A*02:01. The differences in HLA genotypes may potentially alter the course of the disease and its transmission. Twit Text FOAVip Association between HLA gene polymorphisms and mortality of COVID-19: An in silico analysis ????Immun Inflamm Dis http://www.kidney.de/pget.php?&tw=1&pmid=33047883 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33047883 #FOAvip English Wikipedia <ref>{{Cite pmid|33047883}}</ref> Association between HLA gene polymorphisms and mortality of COVID-19: An in silico analysis #MMPMID33047883 Tomita Y; Ikeda T; Sato R; Sakagami T Immun Inflamm Dis 2020[Dec]; 8 (4): 684-694 PMID33047883show ga INTRODUCTION: The emergence of SARS-CoV-2 has caused global public health and economic crisis. Human leukocyte antigen (HLA) is a critical component of the viral antigen presentation pathway and plays essential roles in conferring differential viral susceptibility and severity of diseases. However, the association between HLA gene polymorphisms and risk for COVID-19 has not been fully elucidated. We hypothesized that HLA genotypes might impact on the differences in morbidity and mortality of COVID-19 across countries. METHODS: We conducted in silico analyses and examined an association of HLA gene polymorphisms with prevalence and mortality of COVID-19 by using publicly available databases. RESULTS: We found that a possible association between HLA-A*02:01 and an increased risk for COVID-19. HLA-A*02:01 had a relatively lower capacity to present SARS-CoV-2 antigens compared with other frequent HLA class I molecules, HLA-A*11:01 or HLA-A*24:02. CONCLUSION: This study suggests that individuals with HLA-A*11:01 or HLA-A*24:02 genotypes may generate efficiently T-cell-mediated antiviral responses to SARS-CoV-2 compared with HLA-A*02:01. The differences in HLA genotypes may potentially alter the course of the disease and its transmission. |Betacoronavirus/*immunology[MESH] |COVID-19[MESH] |Computer Simulation[MESH] |Coronavirus Infections/genetics/immunology/*mortality/transmission[MESH] |Gene Frequency[MESH] |Genetic Predisposition to Disease[MESH] |HLA-A Antigens/*genetics[MESH] |Host-Pathogen Interactions/genetics/immunology[MESH] |Humans[MESH] |Linear Models[MESH] |Pandemics[MESH] |Pneumonia, Viral/genetics/immunology/*mortality/transmission[MESH] |Polymorphism, Genetic[MESH] |Prevalence[MESH]Association between HLA gene polymorphisms and mortality of COVID-19: (epmc).pdf DeepDyve Pubget Overpricing