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10.1111/1751-7915.13675 http://scihub22266oqcxt.onion/10.1111/1751-7915.13675 33047877!7675739!33047877     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Microb+Biotechnol 2021 ; 14 (1): 94-110 Nephropedia Template TP {{tp|p=33047877|t=2021. Repositioning microbial biotechnology against COVID-19: the case of microbial production of flavonoids |pdf=|usr=}}{{33047877}} gab.com Text Repositioning microbial biotechnology against COVID-19: the case of microbial production of flavonoids JO: Microb Biotechnol http://www.kidney.de/pget.php?&tw=1&pmid=33047877 #FOAvip Coronavirus-related disease 2019 (COVID-19) became a pandemic in February 2020, and worldwide researchers try to tackle the disease with approved drugs of all kinds, or to develop novel compounds inhibiting viral spreading. Flavonoids, already investigated as antivirals in general, also might bear activities specific for the viral agent causing COVID-19, SARS-CoV-2. Microbial biotechnology and especially synthetic biology may help to produce flavonoids, which are exclusive plant secondary metabolites, at a larger scale or indeed to find novel pharmaceutically active flavonoids. Here, we review the state of the art in (i) antiviral activity of flavonoids specific for coronaviruses and (ii) results derived from computational studies, mostly docking studies mainly inhibiting specific coronaviral proteins such as the 3CL (main) protease, the spike protein or the RNA-dependent RNA polymerase. In the end, we strive towards a synthetic biology pipeline making the fast and tailored production of valuable antiviral flavonoids possible by applying the last concepts of division of labour through co-cultivation/microbial community approaches to the DBTL (Design, Build, Test, Learn) principle. Twit Text FOAVip Repositioning microbial biotechnology against COVID-19: the case of microbial production of flavonoids ????Microb Biotechnol http://www.kidney.de/pget.php?&tw=1&pmid=33047877 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33047877 #FOAvip English Wikipedia <ref>{{Cite pmid|33047877}}</ref> Repositioning microbial biotechnology against COVID-19: the case of microbial production of flavonoids #MMPMID33047877 Goris T; Perez-Valero A; Martinez I; Yi D; Fernandez-Calleja L; San Leon D; Bornscheuer UT; Magadan-Corpas P; Lombo F; Nogales J Microb Biotechnol 2021[Jan]; 14 (1): 94-110 PMID33047877show ga Coronavirus-related disease 2019 (COVID-19) became a pandemic in February 2020, and worldwide researchers try to tackle the disease with approved drugs of all kinds, or to develop novel compounds inhibiting viral spreading. Flavonoids, already investigated as antivirals in general, also might bear activities specific for the viral agent causing COVID-19, SARS-CoV-2. Microbial biotechnology and especially synthetic biology may help to produce flavonoids, which are exclusive plant secondary metabolites, at a larger scale or indeed to find novel pharmaceutically active flavonoids. Here, we review the state of the art in (i) antiviral activity of flavonoids specific for coronaviruses and (ii) results derived from computational studies, mostly docking studies mainly inhibiting specific coronaviral proteins such as the 3CL (main) protease, the spike protein or the RNA-dependent RNA polymerase. In the end, we strive towards a synthetic biology pipeline making the fast and tailored production of valuable antiviral flavonoids possible by applying the last concepts of division of labour through co-cultivation/microbial community approaches to the DBTL (Design, Build, Test, Learn) principle. |*COVID-19 Drug Treatment[MESH] |Antiviral Agents/pharmacology[MESH] |Biotechnology/*methods[MESH] |Drug Discovery/*methods[MESH] |Exocytosis/drug effects[MESH] |Flavonoids/pharmacology/*therapeutic use[MESH] |Microbiota[MESH] |Molecular Docking Simulation[MESH] |SARS-CoV-2/*drug effects[MESH] |Spike Glycoprotein, Coronavirus/chemistry[MESH] |Virus Internalization/drug effects[MESH]Repositioning microbial biotechnology against COVID-19: the case of mi(epmc).pdf DeepDyve Pubget Overpricing