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10.1038/s41467-020-18781-2 http://scihub22266oqcxt.onion/10.1038/s41467-020-18781-2 33046696!7550582!33046696     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2020 ; 11 (1): 5139 Nephropedia Template TP {{tp|p=33046696|t=2020. Type 2 and interferon inflammation regulate SARS-CoV-2 entry factor expression in the airway epithelium |pdf=|usr=}}{{33046696}} gab.com Text Type 2 and interferon inflammation regulate SARS-CoV-2 entry factor expression in the airway epithelium JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=33046696 #FOAvip Coronavirus disease 2019 (COVID-19) is caused by SARS-CoV-2, an emerging virus that utilizes host proteins ACE2 and TMPRSS2 as entry factors. Understanding the factors affecting the pattern and levels of expression of these genes is important for deeper understanding of SARS-CoV-2 tropism and pathogenesis. Here we explore the role of genetics and co-expression networks in regulating these genes in the airway, through the analysis of nasal airway transcriptome data from 695 children. We identify expression quantitative trait loci for both ACE2 and TMPRSS2, that vary in frequency across world populations. We find TMPRSS2 is part of a mucus secretory network, highly upregulated by type 2 (T2) inflammation through the action of interleukin-13, and that the interferon response to respiratory viruses highly upregulates ACE2 expression. IL-13 and virus infection mediated effects on ACE2 expression were also observed at the protein level in the airway epithelium. Finally, we define airway responses to common coronavirus infections in children, finding that these infections generate host responses similar to other viral species, including upregulation of IL6 and ACE2. Our results reveal possible mechanisms influencing SARS-CoV-2 infectivity and COVID-19 clinical outcomes. Twit Text FOAVip Type 2 and interferon inflammation regulate SARS-CoV-2 entry factor expression in the airway epithelium ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=33046696 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33046696 #FOAvip English Wikipedia <ref>{{Cite pmid|33046696}}</ref> Type 2 and interferon inflammation regulate SARS-CoV-2 entry factor expression in the airway epithelium #MMPMID33046696 Sajuthi SP; DeFord P; Li Y; Jackson ND; Montgomery MT; Everman JL; Rios CL; Pruesse E; Nolin JD; Plender EG; Wechsler ME; Mak ACY; Eng C; Salazar S; Medina V; Wohlford EM; Huntsman S; Nickerson DA; Germer S; Zody MC; Abecasis G; Kang HM; Rice KM; Kumar R; Oh S; Rodriguez-Santana J; Burchard EG; Seibold MA Nat Commun 2020[Oct]; 11 (1): 5139 PMID33046696show ga Coronavirus disease 2019 (COVID-19) is caused by SARS-CoV-2, an emerging virus that utilizes host proteins ACE2 and TMPRSS2 as entry factors. Understanding the factors affecting the pattern and levels of expression of these genes is important for deeper understanding of SARS-CoV-2 tropism and pathogenesis. Here we explore the role of genetics and co-expression networks in regulating these genes in the airway, through the analysis of nasal airway transcriptome data from 695 children. We identify expression quantitative trait loci for both ACE2 and TMPRSS2, that vary in frequency across world populations. We find TMPRSS2 is part of a mucus secretory network, highly upregulated by type 2 (T2) inflammation through the action of interleukin-13, and that the interferon response to respiratory viruses highly upregulates ACE2 expression. IL-13 and virus infection mediated effects on ACE2 expression were also observed at the protein level in the airway epithelium. Finally, we define airway responses to common coronavirus infections in children, finding that these infections generate host responses similar to other viral species, including upregulation of IL6 and ACE2. Our results reveal possible mechanisms influencing SARS-CoV-2 infectivity and COVID-19 clinical outcomes. |Angiotensin-Converting Enzyme 2[MESH] |Betacoronavirus/*physiology[MESH] |COVID-19[MESH] |Child[MESH] |Coronavirus Infections/metabolism/pathology/*virology[MESH] |Epithelial Cells/metabolism[MESH] |Gene Expression Profiling[MESH] |Gene Expression Regulation[MESH] |Genetic Variation[MESH] |Host-Pathogen Interactions[MESH] |Humans[MESH] |Inflammation[MESH] |Interferons/*metabolism[MESH] |Interleukin-13/*metabolism[MESH] |Middle Aged[MESH] |Nasal Mucosa/metabolism/*pathology[MESH] |Pandemics[MESH] |Peptidyl-Dipeptidase A/*genetics/metabolism[MESH] |Pneumonia, Viral/metabolism/pathology/*virology[MESH] |SARS-CoV-2[MESH] |Serine Endopeptidases/*genetics/metabolism[MESH]Type 2 and interferon inflammation regulate SARS-CoV-2 entry factor ex(epmc).pdf DeepDyve Pubget Overpricing