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10.1016/j.ejphar.2020.173630 http://scihub22266oqcxt.onion/10.1016/j.ejphar.2020.173630 33045197!7546998!33045197     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Eur+J+Pharmacol 2021 ; 890 (ä): 173630 Nephropedia Template TP {{tp|p=33045197|t=2021. Artesunate protects immunosuppression mice induced by glucocorticoids via enhancing pro-inflammatory cytokines release and bacterial clearance |pdf=|usr=}}{{33045197}} gab.com Text Artesunate protects immunosuppression mice induced by glucocorticoids via enhancing pro-inflammatory cytokines release and bacterial clearance JO: Eur J Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=33045197 #FOAvip Glucocorticoids are commonly used in clinic, but the immunosuppression seriously hinders their usage. Herein, immunomodulatory effect of artesunate (AS) on hydrocortisone (HC)-induced immunosuppression was investigated. HC-induced immunosuppression mice (HC mice) were established by intramuscular administration with HC (20 mg/kg) once a day for 5 consecutive days. The results showed HC mice challenged with Escherichia coli on the sixth day presented a lower ability to clear bacteria, decreased TNF-alpha in blood, decreased spleen index and thymus index. Significantly, AS (20 mg/kg) treatment not only enhanced the ability of HC mice to clear bacteria, but also increased spleen index, the levels of pro-inflammatory cytokines from 78.7 +/- 12.1 ng/ml (TNF-alpha) and 48.7 +/- 8.6 pg/ml (IL-6) to 174.0 +/- 90.5 ng/ml and 783.3 +/- 90.5 pg/ml, number of white blood cells in blood, and sIgA in colon. Subsequently, HC-induced immunosuppression peritoneal macrophages model (HC cells) was established via addition of HC (0.5 mug/ml) for 0.5 h, and then LPS (100 ng/ml) was added to clarify the functional status of the cells. The results showed HC inhibited TNF-alpha and IL-6 mRNA expressions and their release, but AS (2.5 mug/ml) could increase TNF-alpha and IL-6 mRNA expressions and their release. AS inhibited GILZ mRNA up-regulated by HC and increases TLR4/NF-kappaB p65 expressions down-regulated by HC. Our findings revealed that AS's effect is closely related to the improvement of the TLR4/NF-kappaB signal transduction pathway via inhibiting the up-regulation of GILZ mRNA, demonstrating AS does possess immunomodulatory effects and is worth further investigation in the future. Twit Text FOAVip Artesunate protects immunosuppression mice induced by glucocorticoids via enhancing pro-inflammatory cytokines release and bacterial clearance ????Eur J Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=33045197 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33045197 #FOAvip English Wikipedia <ref>{{Cite pmid|33045197}}</ref> Artesunate protects immunosuppression mice induced by glucocorticoids via enhancing pro-inflammatory cytokines release and bacterial clearance #MMPMID33045197 Wang Y; Liao M; Zhang Y; Deng F; Luo J; Wang N; Liu M; Ao L; Fang Q; Wang Q; Zhou H Eur J Pharmacol 2021[Jan]; 890 (ä): 173630 PMID33045197show ga Glucocorticoids are commonly used in clinic, but the immunosuppression seriously hinders their usage. Herein, immunomodulatory effect of artesunate (AS) on hydrocortisone (HC)-induced immunosuppression was investigated. HC-induced immunosuppression mice (HC mice) were established by intramuscular administration with HC (20 mg/kg) once a day for 5 consecutive days. The results showed HC mice challenged with Escherichia coli on the sixth day presented a lower ability to clear bacteria, decreased TNF-alpha in blood, decreased spleen index and thymus index. Significantly, AS (20 mg/kg) treatment not only enhanced the ability of HC mice to clear bacteria, but also increased spleen index, the levels of pro-inflammatory cytokines from 78.7 +/- 12.1 ng/ml (TNF-alpha) and 48.7 +/- 8.6 pg/ml (IL-6) to 174.0 +/- 90.5 ng/ml and 783.3 +/- 90.5 pg/ml, number of white blood cells in blood, and sIgA in colon. Subsequently, HC-induced immunosuppression peritoneal macrophages model (HC cells) was established via addition of HC (0.5 mug/ml) for 0.5 h, and then LPS (100 ng/ml) was added to clarify the functional status of the cells. The results showed HC inhibited TNF-alpha and IL-6 mRNA expressions and their release, but AS (2.5 mug/ml) could increase TNF-alpha and IL-6 mRNA expressions and their release. AS inhibited GILZ mRNA up-regulated by HC and increases TLR4/NF-kappaB p65 expressions down-regulated by HC. Our findings revealed that AS's effect is closely related to the improvement of the TLR4/NF-kappaB signal transduction pathway via inhibiting the up-regulation of GILZ mRNA, demonstrating AS does possess immunomodulatory effects and is worth further investigation in the future. |Animals[MESH] |Artesunate/*pharmacology/therapeutic use[MESH] |Bacteria/*immunology[MESH] |Bacterial Load/drug effects[MESH] |Cells, Cultured[MESH] |Cytokines/drug effects/*metabolism[MESH] |Disease Models, Animal[MESH] |Glucocorticoids/toxicity[MESH] |Immunoglobulin A, Secretory/metabolism[MESH] |Immunologic Factors/*pharmacology/therapeutic use[MESH] |Immunosuppression Therapy[MESH] |Interleukin-6/metabolism[MESH] |Leukocytes/drug effects[MESH] |Macrophages, Peritoneal/metabolism[MESH] |Male[MESH] |Mice[MESH] |Mice, Inbred BALB C[MESH] |Spleen/drug effects/pathology[MESH] |Thymus Gland/drug effects/pathology[MESH] |Toll-Like Receptor 4/metabolism[MESH] |Transcription Factor RelA/metabolism[MESH] |Transcription Factors/metabolism[MESH]Artesunate protects immunosuppression mice induced by glucocorticoids (epmc).pdf DeepDyve Pubget Overpricing