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10.1016/j.matt.2020.09.021 http://scihub22266oqcxt.onion/10.1016/j.matt.2020.09.021 33043290!7535620!33043290     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Matter 2020 ; 3 (5): 1589-1600 Nephropedia Template TP {{tp|p=33043290|t=2020. Reducing False Negatives in COVID-19 Testing by Using Microneedle-Based Oropharyngeal Swabs |pdf=|usr=}}{{33043290}} gab.com Text Reducing False Negatives in COVID-19 Testing by Using Microneedle-Based Oropharyngeal Swabs JO: Matter http://www.kidney.de/pget.php?&tw=1&pmid=33043290 #FOAvip Coronavirus disease 2019 (COVID-19) has become a severe threat to human health worldwide. Early etiological diagnosis plays a critical role in controlling COVID-19 pandemic. However, etiological diagnosis has been largely compromised by high "false-negative" rates of viral nucleic acid testing, resulting from limited sampling efficiency using conventional oropharyngeal swabs. Here, we engineer regular swabs by using a microneedle (MN) patch to significantly improve the quality and quantity of virus collection. The combination of MNs with different crosslinking levels endows the patches with dual capability of mucus penetration and virus extraction. Moreover, the antibody (Ab) against viral spike protein was integrated into the patch, conferring MNs with an active virus capture potential. By taking advantage of the biological and engineered species, we believe that the designed MN/Ab swabs could serve as a promising tool to improve current sampling efficiency with fewer false negatives, contributing to the containment of the COVID-19 pandemic. Twit Text FOAVip Reducing False Negatives in COVID-19 Testing by Using Microneedle-Based Oropharyngeal Swabs ????Matter http://www.kidney.de/pget.php?&tw=1&pmid=33043290 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33043290 #FOAvip English Wikipedia <ref>{{Cite pmid|33043290}}</ref> Reducing False Negatives in COVID-19 Testing by Using Microneedle-Based Oropharyngeal Swabs #MMPMID33043290 Chen W; Cai B; Geng Z; Chen F; Wang Z; Wang L; Chen X Matter 2020[Nov]; 3 (5): 1589-1600 PMID33043290show ga Coronavirus disease 2019 (COVID-19) has become a severe threat to human health worldwide. Early etiological diagnosis plays a critical role in controlling COVID-19 pandemic. However, etiological diagnosis has been largely compromised by high "false-negative" rates of viral nucleic acid testing, resulting from limited sampling efficiency using conventional oropharyngeal swabs. Here, we engineer regular swabs by using a microneedle (MN) patch to significantly improve the quality and quantity of virus collection. The combination of MNs with different crosslinking levels endows the patches with dual capability of mucus penetration and virus extraction. Moreover, the antibody (Ab) against viral spike protein was integrated into the patch, conferring MNs with an active virus capture potential. By taking advantage of the biological and engineered species, we believe that the designed MN/Ab swabs could serve as a promising tool to improve current sampling efficiency with fewer false negatives, contributing to the containment of the COVID-19 pandemic. äReducing False Negatives in COVID-19 Testing by Using Microneedle-Base(epmc).pdf DeepDyve Pubget Overpricing