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10.1016/j.isci.2020.101645 http://scihub22266oqcxt.onion/10.1016/j.isci.2020.101645 33043283!7534591!33043283     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       iScience 2020 ; 23 (10): 101645 Nephropedia Template TP {{tp|p=33043283|t=2020. SARS-CoV-2 Infection Dysregulates the Metabolomic and Lipidomic Profiles of Serum |pdf=|usr=}}{{33043283}} gab.com Text SARS-CoV-2 Infection Dysregulates the Metabolomic and Lipidomic Profiles of Serum JO: iScience http://www.kidney.de/pget.php?&tw=1&pmid=33043283 #FOAvip COVID-19 is a systemic infection that exerts significant impact on the metabolism. Yet, there is little information on how SARS-CoV-2 affects metabolism. Using NMR spectroscopy, we measured the metabolomic and lipidomic serum profile from 263 (training cohort) + 135 (validation cohort) symptomatic patients hospitalized after positive PCR testing for SARS-CoV-2 infection. We also established the profiles of 280 persons collected before the coronavirus pandemic started. Principal-component analysis discriminated both cohorts, highlighting the impact that the infection has on overall metabolism. The lipidomic analysis unraveled a pathogenic redistribution of the lipoprotein particle size and composition to increase the atherosclerotic risk. In turn, metabolomic analysis reveals abnormally high levels of ketone bodies (acetoacetic acid, 3-hydroxybutyric acid, and acetone) and 2-hydroxybutyric acid, a readout of hepatic glutathione synthesis and marker of oxidative stress. Our results are consistent with a model in which SARS-CoV-2 infection induces liver damage associated with dyslipidemia and oxidative stress. Twit Text FOAVip SARS-CoV-2 Infection Dysregulates the Metabolomic and Lipidomic Profiles of Serum ????iScience http://www.kidney.de/pget.php?&tw=1&pmid=33043283 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33043283 #FOAvip English Wikipedia <ref>{{Cite pmid|33043283}}</ref> SARS-CoV-2 Infection Dysregulates the Metabolomic and Lipidomic Profiles of Serum #MMPMID33043283 Bruzzone C; Bizkarguenaga M; Gil-Redondo R; Diercks T; Arana E; Garcia de Vicuna A; Seco M; Bosch A; Palazon A; San Juan I; Lain A; Gil-Martinez J; Bernardo-Seisdedos G; Fernandez-Ramos D; Lopitz-Otsoa F; Embade N; Lu S; Mato JM; Millet O iScience 2020[Oct]; 23 (10): 101645 PMID33043283show ga COVID-19 is a systemic infection that exerts significant impact on the metabolism. Yet, there is little information on how SARS-CoV-2 affects metabolism. Using NMR spectroscopy, we measured the metabolomic and lipidomic serum profile from 263 (training cohort) + 135 (validation cohort) symptomatic patients hospitalized after positive PCR testing for SARS-CoV-2 infection. We also established the profiles of 280 persons collected before the coronavirus pandemic started. Principal-component analysis discriminated both cohorts, highlighting the impact that the infection has on overall metabolism. The lipidomic analysis unraveled a pathogenic redistribution of the lipoprotein particle size and composition to increase the atherosclerotic risk. In turn, metabolomic analysis reveals abnormally high levels of ketone bodies (acetoacetic acid, 3-hydroxybutyric acid, and acetone) and 2-hydroxybutyric acid, a readout of hepatic glutathione synthesis and marker of oxidative stress. Our results are consistent with a model in which SARS-CoV-2 infection induces liver damage associated with dyslipidemia and oxidative stress. äSARS-CoV-2 Infection Dysregulates the Metabolomic and Lipidomic Profil(epmc).pdf DeepDyve Pubget Overpricing