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10.1016/j.isci.2020.101642 http://scihub22266oqcxt.onion/10.1016/j.isci.2020.101642 33043282!7534598!33043282     free     free     free       iScience 2020 ; 23 (10): 101642 Nephropedia Template TP {{tp|p=33043282|t=2020. Furin: A Potential Therapeutic Target for COVID-19 |pdf=|usr=}}{{33043282}} gab.com Text Furin: A Potential Therapeutic Target for COVID-19 JO: iScience http://www.kidney.de/pget.php?&tw=1&pmid=33043282 #FOAvip COVID-19 broke out in the end of December 2019 and is still spreading rapidly, which has been listed as an international concerning public health emergency. We found that the Spike protein of SARS-CoV-2 contains a furin cleavage site, which did not exist in any other betacoronavirus subtype B. Based on a series of analysis, we speculate that the presence of a redundant furin cut site in its Spike protein is responsible for SARS-CoV-2's stronger infectious nature than other coronaviruses, which leads to higher membrane fusion efficiency. Subsequently, a library of 4,000 compounds including approved drugs and natural products was screened against furin through structure-based virtual screening and then assayed for their inhibitory effects on furin activity. Among them, an anti-parasitic drug, diminazene, showed the highest inhibition effects on furin with an IC(50) of 5.42 +/- 0.11 muM, which might be used for the treatment of COVID-19. Twit Text FOAVip Furin: A Potential Therapeutic Target for COVID-19 ????iScience http://www.kidney.de/pget.php?&tw=1&pmid=33043282 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33043282 #FOAvip English Wikipedia <ref>{{Cite pmid|33043282}}</ref> Furin: A Potential Therapeutic Target for COVID-19 #MMPMID33043282 Wu C; Zheng M; Yang Y; Gu X; Yang K; Li M; Liu Y; Zhang Q; Zhang P; Wang Y; Wang Q; Xu Y; Zhou Y; Zhang Y; Chen L; Li H iScience 2020[Oct]; 23 (10): 101642 PMID33043282show ga COVID-19 broke out in the end of December 2019 and is still spreading rapidly, which has been listed as an international concerning public health emergency. We found that the Spike protein of SARS-CoV-2 contains a furin cleavage site, which did not exist in any other betacoronavirus subtype B. Based on a series of analysis, we speculate that the presence of a redundant furin cut site in its Spike protein is responsible for SARS-CoV-2's stronger infectious nature than other coronaviruses, which leads to higher membrane fusion efficiency. Subsequently, a library of 4,000 compounds including approved drugs and natural products was screened against furin through structure-based virtual screening and then assayed for their inhibitory effects on furin activity. Among them, an anti-parasitic drug, diminazene, showed the highest inhibition effects on furin with an IC(50) of 5.42 +/- 0.11 muM, which might be used for the treatment of COVID-19. ?Furin: A Potential Therapeutic Target for COVID-19 (epmc).pdf DeepDyve Pubget Overpricing