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10.1002/advs.202001300 http://scihub22266oqcxt.onion/10.1002/advs.202001300 33042732!7536916!33042732     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Adv+Sci+(Weinh) 2020 ; 7 (20): 2001300 Nephropedia Template TP {{tp|p=33042732|t=2020. MeCas12a, a Highly Sensitive and Specific System for COVID-19 Detection |pdf=|usr=}}{{33042732}} gab.com Text MeCas12a, a Highly Sensitive and Specific System for COVID-19 Detection JO: Adv Sci (Weinh) http://www.kidney.de/pget.php?&tw=1&pmid=33042732 #FOAvip Cas12a-based systems, which detect specific nucleic acids via collateral cleavage of reporter DNA, display huge potentials for rapid diagnosis of infectious diseases. Here, the Manganese-enhanced Cas12a (MeCas12a) system is described, where manganese is used to increase the detection sensitivity up to 13-fold, enabling the detection of target RNAs as low as five copies. MeCas12a is also highly specific, and is able to distinguish between single nucleotide polymorphisms (SNPs) differing by a single nucleotide. MeCas12a can detect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in clinical samples and distinguish between SARS-CoV-2 and Middle East respiratory syndrome coronavirus (MERS-CoV) RNA in simulated samples, thus offering an attractive alternative to other methods for the diagnosis of infectious diseases including COVID-19 and MERS. Twit Text FOAVip MeCas12a, a Highly Sensitive and Specific System for COVID-19 Detection ????Adv Sci (Weinh) http://www.kidney.de/pget.php?&tw=1&pmid=33042732 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33042732 #FOAvip English Wikipedia <ref>{{Cite pmid|33042732}}</ref> MeCas12a, a Highly Sensitive and Specific System for COVID-19 Detection #MMPMID33042732 Ma P; Meng Q; Sun B; Zhao B; Dang L; Zhong M; Liu S; Xu H; Mei H; Liu J; Chi T; Yang G; Liu M; Huang X; Wang X Adv Sci (Weinh) 2020[Oct]; 7 (20): 2001300 PMID33042732show ga Cas12a-based systems, which detect specific nucleic acids via collateral cleavage of reporter DNA, display huge potentials for rapid diagnosis of infectious diseases. Here, the Manganese-enhanced Cas12a (MeCas12a) system is described, where manganese is used to increase the detection sensitivity up to 13-fold, enabling the detection of target RNAs as low as five copies. MeCas12a is also highly specific, and is able to distinguish between single nucleotide polymorphisms (SNPs) differing by a single nucleotide. MeCas12a can detect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in clinical samples and distinguish between SARS-CoV-2 and Middle East respiratory syndrome coronavirus (MERS-CoV) RNA in simulated samples, thus offering an attractive alternative to other methods for the diagnosis of infectious diseases including COVID-19 and MERS. äMeCas12a, a Highly Sensitive and Specific System for COVID-19 Detectio(epmc).pdf DeepDyve Pubget Overpricing