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10.1016/j.arcontrol.2020.09.008

http://scihub22266oqcxt.onion/10.1016/j.arcontrol.2020.09.008
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33041634!7538078!33041634
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suck abstract from ncbi

pmid33041634      Annu+Rev+Control 2020 ; 50 (ä): 457-468
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  • Characterization of SARS-CoV-2 dynamics in the host #MMPMID33041634
  • Abuin P; Anderson A; Ferramosca A; Hernandez-Vargas EA; Gonzalez AH
  • Annu Rev Control 2020[]; 50 (ä): 457-468 PMID33041634show ga
  • While many epidemiological models were proposed to understand and handle COVID-19 pandemic, too little has been invested to understand human viral replication and the potential use of novel antivirals to tackle the infection. In this work, using a control theoretical approach, validated mathematical models of SARS-CoV-2 in humans are characterized. A complete analysis of the main dynamic characteristic is developed based on the reproduction number. The equilibrium regions of the system are fully characterized, and the stability of such regions is formally established. Mathematical analysis highlights critical conditions to decrease monotonically SARS-CoV-2 in the host, as such conditions are relevant to tailor future antiviral treatments. Simulation results show the aforementioned system characterization.
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