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10.1038/s41401-020-00537-9 http://scihub22266oqcxt.onion/10.1038/s41401-020-00537-9 33041326!7548405!33041326     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Acta+Pharmacol+Sin 2021 ; 42 (7): 1195-1200 Nephropedia Template TP {{tp|p=33041326|t=2021. Pharmacokinetics and tissue distribution of remdesivir and its metabolites nucleotide monophosphate, nucleotide triphosphate, and nucleoside in mice |pdf=|usr=}}{{33041326}} gab.com Text Pharmacokinetics and tissue distribution of remdesivir and its metabolites nucleotide monophosphate, nucleotide triphosphate, and nucleoside in mice JO: Acta Pharmacol Sin http://www.kidney.de/pget.php?&tw=1&pmid=33041326 #FOAvip Remdesivir (RDV) exerts anti-severe acute respiratory coronavirus 2 activity following metabolic activation in the target tissues. However, the pharmacokinetics and tissue distributions of the parent drug and its active metabolites have been poorly characterized to date. Blood and tissue levels were evaluated in the current study. After intravenous administration of 20 mg/kg RDV in mice, the concentrations of the parent drug, nucleotide monophosphate (RMP) and triphosphate (RTP), as well as nucleoside (RN), in the blood, heart, liver, lung, kidney, testis, and small intestine were quantified. In blood, RDV was rapidly and completely metabolized and was barely detected at 0.5 h, similar to RTP, while its metabolites RMP and RN exhibited higher blood levels with increased residence times. The area under the concentration versus time curve up to the last measured point in time (AUC(0-t)) values of RMP and RN were 4558 and 136,572 h?nM, respectively. The maximum plasma concentration (C(max)) values of RMP and RN were 2896 nM and 35,819 nM, respectively. Moreover, RDV presented an extensive distribution, and the lung, liver and kidney showed high levels of the parent drug and metabolites. The metabolic stabilities of RDV and RMP were also evaluated using lung, liver, and kidney microsomes. RDV showed higher clearances in the liver and kidney than in the lung, with intrinsic clearance (CL(int)) values of 1740, 1253, and 127 mL/(min?g microsomal protein), respectively. Twit Text FOAVip Pharmacokinetics and tissue distribution of remdesivir and its metabolites nucleotide monophosphate, nucleotide triphosphate, and nucleoside in mice ????Acta Pharmacol Sin http://www.kidney.de/pget.php?&tw=1&pmid=33041326 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33041326 #FOAvip English Wikipedia <ref>{{Cite pmid|33041326}}</ref> Pharmacokinetics and tissue distribution of remdesivir and its metabolites nucleotide monophosphate, nucleotide triphosphate, and nucleoside in mice #MMPMID33041326 Hu WJ; Chang L; Yang Y; Wang X; Xie YC; Shen JS; Tan B; Liu J Acta Pharmacol Sin 2021[Jul]; 42 (7): 1195-1200 PMID33041326show ga Remdesivir (RDV) exerts anti-severe acute respiratory coronavirus 2 activity following metabolic activation in the target tissues. However, the pharmacokinetics and tissue distributions of the parent drug and its active metabolites have been poorly characterized to date. Blood and tissue levels were evaluated in the current study. After intravenous administration of 20 mg/kg RDV in mice, the concentrations of the parent drug, nucleotide monophosphate (RMP) and triphosphate (RTP), as well as nucleoside (RN), in the blood, heart, liver, lung, kidney, testis, and small intestine were quantified. In blood, RDV was rapidly and completely metabolized and was barely detected at 0.5 h, similar to RTP, while its metabolites RMP and RN exhibited higher blood levels with increased residence times. The area under the concentration versus time curve up to the last measured point in time (AUC(0-t)) values of RMP and RN were 4558 and 136,572 h?nM, respectively. The maximum plasma concentration (C(max)) values of RMP and RN were 2896 nM and 35,819 nM, respectively. Moreover, RDV presented an extensive distribution, and the lung, liver and kidney showed high levels of the parent drug and metabolites. The metabolic stabilities of RDV and RMP were also evaluated using lung, liver, and kidney microsomes. RDV showed higher clearances in the liver and kidney than in the lung, with intrinsic clearance (CL(int)) values of 1740, 1253, and 127 mL/(min?g microsomal protein), respectively. |Adenosine Monophosphate/*analogs & derivatives/pharmacokinetics/pharmacology[MESH] |Alanine/*analogs & derivatives/pharmacokinetics/pharmacology[MESH] |Animals[MESH] |Antiviral Agents/pharmacokinetics/pharmacology[MESH] |COVID-19 Drug Treatment[MESH] |COVID-19/metabolism[MESH] |Kidney/metabolism[MESH] |Liver/metabolism[MESH] |Lung/metabolism[MESH] |Male[MESH] |Mice[MESH] |Nucleosides/*metabolism[MESH] |Nucleotides/*metabolism[MESH] |Polyphosphates/*metabolism[MESH] |SARS-CoV-2/drug effects[MESH]Pharmacokinetics and tissue distribution of remdesivir and its metabol(epmc).pdf DeepDyve Pubget Overpricing