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10.1016/j.it.2020.09.004 http://scihub22266oqcxt.onion/10.1016/j.it.2020.09.004 33041212!7498231!33041212     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Trends+Immunol 2020 ; 41 (11): 1006-1022 Nephropedia Template TP {{tp|p=33041212|t=2020. Structural Basis of SARS-CoV-2 and SARS-CoV Antibody Interactions |pdf=|usr=}}{{33041212}} gab.com Text Structural Basis of SARS-CoV-2 and SARS-CoV Antibody Interactions JO: Trends Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33041212 #FOAvip The 2019 coronavirus pandemic remains a major public health concern. Neutralizing antibodies (nAbs) represent a cutting-edge antiviral strategy. We focus here on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and SARS-CoV, and discuss current progress in antibody research against rampant SARS-CoV-2 infections. We provide a perspective on the mechanisms of SARS-CoV-2-derived nAbs, comparing these with existing SARS-CoV-derived antibodies. We offer insight into how these antibodies cross-react and cross-neutralize by analyzing available structures of spike (S) glycoprotein-antibody complexes. We also propose ways of adopting antibody-based strategies - such as cocktail antibody therapeutics against SARS-CoV-2 - to overcome the possible resistance of currently identified mutants and mitigate possible antibody-dependent enhancement (ADE) pathologies. This review provides a platform for the progression of antibody and vaccine design against SARS-CoV-2, and possibly against future coronavirus pandemics. Twit Text FOAVip Structural Basis of SARS-CoV-2 and SARS-CoV Antibody Interactions ????Trends Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33041212 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33041212 #FOAvip English Wikipedia <ref>{{Cite pmid|33041212}}</ref> Structural Basis of SARS-CoV-2 and SARS-CoV Antibody Interactions #MMPMID33041212 Gavor E; Choong YK; Er SY; Sivaraman H; Sivaraman J Trends Immunol 2020[Nov]; 41 (11): 1006-1022 PMID33041212show ga The 2019 coronavirus pandemic remains a major public health concern. Neutralizing antibodies (nAbs) represent a cutting-edge antiviral strategy. We focus here on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and SARS-CoV, and discuss current progress in antibody research against rampant SARS-CoV-2 infections. We provide a perspective on the mechanisms of SARS-CoV-2-derived nAbs, comparing these with existing SARS-CoV-derived antibodies. We offer insight into how these antibodies cross-react and cross-neutralize by analyzing available structures of spike (S) glycoprotein-antibody complexes. We also propose ways of adopting antibody-based strategies - such as cocktail antibody therapeutics against SARS-CoV-2 - to overcome the possible resistance of currently identified mutants and mitigate possible antibody-dependent enhancement (ADE) pathologies. This review provides a platform for the progression of antibody and vaccine design against SARS-CoV-2, and possibly against future coronavirus pandemics. |Animals[MESH] |Antibodies, Monoclonal/*immunology/metabolism[MESH] |Antibodies, Neutralizing/*immunology/metabolism[MESH] |Antibodies, Viral/*immunology/metabolism[MESH] |Betacoronavirus/*immunology/metabolism/physiology[MESH] |COVID-19[MESH] |COVID-19 Vaccines[MESH] |Coronavirus Infections/*immunology/prevention & control/virology[MESH] |Humans[MESH] |Pandemics/prevention & control[MESH] |Pneumonia, Viral/*immunology/prevention & control/virology[MESH] |Protein Binding[MESH] |SARS-CoV-2[MESH] |Severe acute respiratory syndrome-related coronavirus/*immunology/metabolism[MESH]Structural Basis of SARS-CoV-2 and SARS-CoV Antibody Interactions (epmc).pdf DeepDyve Pubget Overpricing