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10.1016/j.phymed.2020.153364 http://scihub22266oqcxt.onion/10.1016/j.phymed.2020.153364 33041173!7531286!33041173     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Phytomedicine 2021 ; 85 (ä): 153364 Nephropedia Template TP {{tp|p=33041173|t=2021. Glycyrrhizic acid exerts inhibitory activity against the spike protein of SARS-CoV-2 |pdf=|usr=}}{{33041173}} gab.com Text Glycyrrhizic acid exerts inhibitory activity against the spike protein of SARS-CoV-2 JO: Phytomedicine http://www.kidney.de/pget.php?&tw=1&pmid=33041173 #FOAvip Coronavirus causes a disease with high infectivity and pathogenicity, especially SARS in 2003, MERS in 2012, and COVID-2019 currently. The spike proteins of these coronaviruses are critical for host cell entry by receptors. Thus, searching for broad-spectrum anti-coronavirus candidates, such as spike protein inhibitors, is vital and desirable due to the mutations in the spike protein. In this study, a combination of computer-aided drug design and biological verification was used to discover active monomers from traditional Chinese medicine. Surface plasmon resonance (SPR) assays and NanoBit assays were used to verify the predicated compounds with their binding activities to spike proteins and inhibitory activities on the SARS-CoV-2 RBD/ACE2 interaction, respectively. Furthermore, an MTT assay was used to evaluate the cell toxicities of active compounds. As a result, glycyrrhizic acid (ZZY-44) was found to be the most efficient and nontoxic broad-spectrum anti-coronavirus molecule in vitro, especially, the significant effect on SARS-CoV-2, which provided a theoretical basis for the study of the pharmacodynamic material basis of traditional Chinese medicine against SARS-CoV-2 and offered a lead compound for further structural modification in order to obtain more effective candidate drugs against SARS-CoV-2. Twit Text FOAVip Glycyrrhizic acid exerts inhibitory activity against the spike protein of SARS-CoV-2 ????Phytomedicine http://www.kidney.de/pget.php?&tw=1&pmid=33041173 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33041173 #FOAvip English Wikipedia <ref>{{Cite pmid|33041173}}</ref> Glycyrrhizic acid exerts inhibitory activity against the spike protein of SARS-CoV-2 #MMPMID33041173 Yu S; Zhu Y; Xu J; Yao G; Zhang P; Wang M; Zhao Y; Lin G; Chen H; Chen L; Zhang J Phytomedicine 2021[May]; 85 (ä): 153364 PMID33041173show ga Coronavirus causes a disease with high infectivity and pathogenicity, especially SARS in 2003, MERS in 2012, and COVID-2019 currently. The spike proteins of these coronaviruses are critical for host cell entry by receptors. Thus, searching for broad-spectrum anti-coronavirus candidates, such as spike protein inhibitors, is vital and desirable due to the mutations in the spike protein. In this study, a combination of computer-aided drug design and biological verification was used to discover active monomers from traditional Chinese medicine. Surface plasmon resonance (SPR) assays and NanoBit assays were used to verify the predicated compounds with their binding activities to spike proteins and inhibitory activities on the SARS-CoV-2 RBD/ACE2 interaction, respectively. Furthermore, an MTT assay was used to evaluate the cell toxicities of active compounds. As a result, glycyrrhizic acid (ZZY-44) was found to be the most efficient and nontoxic broad-spectrum anti-coronavirus molecule in vitro, especially, the significant effect on SARS-CoV-2, which provided a theoretical basis for the study of the pharmacodynamic material basis of traditional Chinese medicine against SARS-CoV-2 and offered a lead compound for further structural modification in order to obtain more effective candidate drugs against SARS-CoV-2. |*Drug Design[MESH] |Animals[MESH] |Glycyrrhizic Acid/*pharmacology[MESH] |HEK293 Cells[MESH] |Humans[MESH] |Medicine, Chinese Traditional[MESH] |Mice[MESH] |Molecular Docking Simulation[MESH] |Plants, Medicinal/chemistry[MESH] |Protein Binding[MESH] |SARS-CoV-2/*drug effects[MESH] |Spike Glycoprotein, Coronavirus/*antagonists & inhibitors[MESH]Glycyrrhizic acid exerts inhibitory activity against the spike protein(epmc).pdf DeepDyve Pubget Overpricing