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10.1134/S0006297920070111

http://scihub22266oqcxt.onion/10.1134/S0006297920070111
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33040727!7356136!33040727
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suck abstract from ncbi


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pmid33040727      Biochemistry+(Mosc) 2020 ; 85 (7): 833-837
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  • Transcription Factor Nrf2 as a Potential Therapeutic Target for Prevention of Cytokine Storm in COVID-19 Patients #MMPMID33040727
  • Zinovkin RA; Grebenchikov OA
  • Biochemistry (Mosc) 2020[Jul]; 85 (7): 833-837 PMID33040727show ga
  • Nrf2 is a key transcription factor responsible for antioxidant defense in many tissues and cells, including alveolar epithelium, endothelium, and macrophages. Furthermore, Nrf2 functions as a transcriptional repressor that inhibits expression of the inflammatory cytokines in macrophages. Critically ill patients with COVID-19 infection often present signs of high oxidative stress and systemic inflammation - the leading causes of mortality. This article suggests rationale for the use of Nrf2 inducers to prevent development of an excessive inflammatory response in COVID-19 patients.
  • |*Betacoronavirus[MESH]
  • |Animals[MESH]
  • |Antioxidants/pharmacology/therapeutic use[MESH]
  • |COVID-19[MESH]
  • |COVID-19 Drug Treatment[MESH]
  • |Catechin/analogs & derivatives/pharmacology/therapeutic use[MESH]
  • |Coronavirus Infections/*drug therapy/*metabolism/virology[MESH]
  • |Cytokines/*antagonists & inhibitors/*metabolism[MESH]
  • |Dimethyl Fumarate/pharmacology/therapeutic use[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Immunosuppressive Agents/pharmacology/therapeutic use[MESH]
  • |Inflammation/metabolism[MESH]
  • |Isothiocyanates/pharmacology/therapeutic use[MESH]
  • |Male[MESH]
  • |Mice[MESH]
  • |Molecular Targeted Therapy/*methods[MESH]
  • |NF-E2-Related Factor 2/*metabolism[MESH]
  • |Oxidative Stress/drug effects[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*drug therapy/*metabolism/virology[MESH]
  • |Respiratory Distress Syndrome/drug therapy/metabolism/virology[MESH]
  • |Resveratrol/pharmacology/therapeutic use[MESH]
  • |SARS-CoV-2[MESH]
  • |Signal Transduction/drug effects[MESH]
  • |Sulfoxides[MESH]


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