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10.1016/j.intimp.2020.107031

http://scihub22266oqcxt.onion/10.1016/j.intimp.2020.107031
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suck abstract from ncbi


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pmid33039964      Int+Immunopharmacol 2020 ; 89 (Pt A): 107031
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  • Risk factors for prolonged viral clearance in adult patients with COVID-19 in Beijing, China: A prospective observational study #MMPMID33039964
  • Xue J; Zheng J; Shang X; Qin E; Zhao P; He Y; Liu M; Zhang J; Liu H; Bai C
  • Int Immunopharmacol 2020[Dec]; 89 (Pt A): 107031 PMID33039964show ga
  • Clearance of COVID-19 from the human body has not been established. Our study collected the laboratory test results from patients and analyzed the correlation between early changes in serum indices and the virus clearance by univariable and multivariable COX regression models, with an aim to explore the risk factors for prolonged viral clearance. The study included 61 patients with COVID-19 treated at the Fifth Medical Center of PLA General Hospital in Beijing from 20 January 2020 to 20 February 2020. We set the total observation of the disease course to 20 days and the patients were divided into two groups (prolonged group, > 20d vs. normal group, 211.5 U/L, an interleukin 6 (IL-6) level > 12.5 pg/ml, and a NK lymphocyte percentage > 0.5% were associated with prolonged viral clearance. Therefore, we showed that a history of hypertension, an elevated IL-6 level, and an elevated percentage of NK cells were risk factors for prolonged viral clearance.
  • |*Virus Shedding[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |COVID-19/immunology/*virology[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Killer Cells, Natural/immunology[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Proportional Hazards Models[MESH]
  • |Prospective Studies[MESH]
  • |RNA, Viral/*analysis[MESH]
  • |Risk Factors[MESH]


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