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10.1016/j.ijid.2020.10.003 http://scihub22266oqcxt.onion/10.1016/j.ijid.2020.10.003 33039609!7544772!33039609     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Infect+Dis 2020 ; 101 (ä): 342-345 Nephropedia Template TP {{tp|p=33039609|t=2020. A score combining early detection of cytokines accurately predicts COVID-19 severity and intensive care unit transfer |pdf=|usr=}}{{33039609}} gab.com Text A score combining early detection of cytokines accurately predicts COVID-19 severity and intensive care unit transfer JO: Int J Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=33039609 #FOAvip OBJECTIVES: We aimed to explore cytokine profile in patients as it relates to Coronavirus Disease 2019 (COVID-19) severity, and to establish a predictive cytokine score to discriminate severe from non-severe cases and provide a prognosis parameter for patients that will require intensive care unit (ICU) transfer. METHODS: Serum samples of 63 patients diagnosed with SARS-CoV-2 infection were collected early after hospital admission (day 0-3). Patients were categorized in five groups based on the clinical presentation, the PaO2/FiO2 ratio and the requirement of mechanical ventilation. RESULTS: Three cytokines, IL-6, IL-8 and IL-10, were markedly higher in severe forms (n = 44) than in non-severe forms (n = 19) (p < 0.005). A score combining levels of these three cytokines (IL-6*IL-8*IL-10) had the highest performance to predict severity: sensitivity of 86.4% (95% CI, 72.4-94.8) and specificity of 94.7% (95% CI, 74.0-99.9) for a cutoff value of 2068 pg/mL. Elevated levels of IL-6, IL-8 and IL-10 were also found in critically ill patients. The combination of IL-6*IL-10 serum levels allowed the highest predictability for ICU transfer: AUC of 0.898 (p < 0.0001). CONCLUSION: The combinatorial IL-6*IL-8*IL-10 score at presentation was highly predictive of the progression to a severe form of the disease, and could contribute to improve patient triage and to adapt therapeutic strategy within clinical trials more accurately and efficiently. Twit Text FOAVip A score combining early detection of cytokines accurately predicts COVID-19 severity and intensive care unit transfer ????Int J Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=33039609 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33039609 #FOAvip English Wikipedia <ref>{{Cite pmid|33039609}}</ref> A score combining early detection of cytokines accurately predicts COVID-19 severity and intensive care unit transfer #MMPMID33039609 Nagant C; Ponthieux F; Smet J; Dauby N; Doyen V; Besse-Hammer T; De Bels D; Maillart E; Corazza F Int J Infect Dis 2020[Dec]; 101 (ä): 342-345 PMID33039609show ga OBJECTIVES: We aimed to explore cytokine profile in patients as it relates to Coronavirus Disease 2019 (COVID-19) severity, and to establish a predictive cytokine score to discriminate severe from non-severe cases and provide a prognosis parameter for patients that will require intensive care unit (ICU) transfer. METHODS: Serum samples of 63 patients diagnosed with SARS-CoV-2 infection were collected early after hospital admission (day 0-3). Patients were categorized in five groups based on the clinical presentation, the PaO2/FiO2 ratio and the requirement of mechanical ventilation. RESULTS: Three cytokines, IL-6, IL-8 and IL-10, were markedly higher in severe forms (n = 44) than in non-severe forms (n = 19) (p < 0.005). A score combining levels of these three cytokines (IL-6*IL-8*IL-10) had the highest performance to predict severity: sensitivity of 86.4% (95% CI, 72.4-94.8) and specificity of 94.7% (95% CI, 74.0-99.9) for a cutoff value of 2068 pg/mL. Elevated levels of IL-6, IL-8 and IL-10 were also found in critically ill patients. The combination of IL-6*IL-10 serum levels allowed the highest predictability for ICU transfer: AUC of 0.898 (p < 0.0001). CONCLUSION: The combinatorial IL-6*IL-8*IL-10 score at presentation was highly predictive of the progression to a severe form of the disease, and could contribute to improve patient triage and to adapt therapeutic strategy within clinical trials more accurately and efficiently. |Adult[MESH] |Aged[MESH] |Aged, 80 and over[MESH] |COVID-19/*blood/diagnosis/therapy/virology[MESH] |Cytokines/*blood[MESH] |Female[MESH] |Hospitalization[MESH] |Humans[MESH] |Intensive Care Units/statistics & numerical data[MESH] |Interleukins/blood[MESH] |Male[MESH] |Middle Aged[MESH] |Pandemics[MESH] |Prognosis[MESH] |Respiration, Artificial[MESH] |SARS-CoV-2/genetics/physiology[MESH] |Severity of Illness Index[MESH]A score combining early detection of cytokines accurately predicts COV(epmc).pdf DeepDyve Pubget Overpricing