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10.1016/j.kint.2020.09.015 http://scihub22266oqcxt.onion/10.1016/j.kint.2020.09.015 33038424!7543950!33038424     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Kidney+Int 2020 ; 98 (6): 1502-1518 Nephropedia Template TP {{tp|p=33038424|t=2020. SARS-CoV-2 receptor networks in diabetic and COVID-19-associated kidney disease |pdf=|usr=}}{{33038424}} gab.com Text SARS-CoV-2 receptor networks in diabetic and COVID-19-associated kidney disease JO: Kidney Int http://www.kidney.de/pget.php?&tw=1&pmid=33038424 #FOAvip COVID-19 morbidity and mortality are increased via unknown mechanisms in patients with diabetes and kidney disease. SARS-CoV-2 uses angiotensin-converting enzyme 2 (ACE2) for entry into host cells. Because ACE2 is a susceptibility factor for infection, we investigated how diabetic kidney disease and medications alter ACE2 receptor expression in kidneys. Single cell RNA profiling of kidney biopsies from healthy living donors and patients with diabetic kidney disease revealed ACE2 expression primarily in proximal tubular epithelial cells. This cell-specific localization was confirmed by in situ hybridization. ACE2 expression levels were unaltered by exposures to renin-angiotensin-aldosterone system inhibitors in diabetic kidney disease. Bayesian integrative analysis of a large compendium of public -omics datasets identified molecular network modules induced in ACE2-expressing proximal tubular epithelial cells in diabetic kidney disease (searchable at hb.flatironinstitute.org/covid-kidney) that were linked to viral entry, immune activation, endomembrane reorganization, and RNA processing. The diabetic kidney disease ACE2-positive proximal tubular epithelial cell module overlapped with expression patterns seen in SARS-CoV-2-infected cells. Similar cellular programs were seen in ACE2-positive proximal tubular epithelial cells obtained from urine samples of 13 hospitalized patients with COVID-19, suggesting a consistent ACE2-coregulated proximal tubular epithelial cell expression program that may interact with the SARS-CoV-2 infection processes. Thus SARS-CoV-2 receptor networks can seed further research into risk stratification and therapeutic strategies for COVID-19-related kidney damage. Twit Text FOAVip SARS-CoV-2 receptor networks in diabetic and COVID-19-associated kidney disease ????Kidney Int http://www.kidney.de/pget.php?&tw=1&pmid=33038424 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33038424 #FOAvip English Wikipedia <ref>{{Cite pmid|33038424}}</ref> SARS-CoV-2 receptor networks in diabetic and COVID-19-associated kidney disease #MMPMID33038424 Menon R; Otto EA; Sealfon R; Nair V; Wong AK; Theesfeld CL; Chen X; Wang Y; Boppana AS; Luo J; Yang Y; Kasson PM; Schaub JA; Berthier CC; Eddy S; Lienczewski CC; Godfrey B; Dagenais SL; Sohaney R; Hartman J; Fermin D; Subramanian L; Looker HC; Harder JL; Mariani LH; Hodgin JB; Sexton JZ; Wobus CE; Naik AS; Nelson RG; Troyanskaya OG; Kretzler M Kidney Int 2020[Dec]; 98 (6): 1502-1518 PMID33038424show ga COVID-19 morbidity and mortality are increased via unknown mechanisms in patients with diabetes and kidney disease. SARS-CoV-2 uses angiotensin-converting enzyme 2 (ACE2) for entry into host cells. Because ACE2 is a susceptibility factor for infection, we investigated how diabetic kidney disease and medications alter ACE2 receptor expression in kidneys. Single cell RNA profiling of kidney biopsies from healthy living donors and patients with diabetic kidney disease revealed ACE2 expression primarily in proximal tubular epithelial cells. This cell-specific localization was confirmed by in situ hybridization. ACE2 expression levels were unaltered by exposures to renin-angiotensin-aldosterone system inhibitors in diabetic kidney disease. Bayesian integrative analysis of a large compendium of public -omics datasets identified molecular network modules induced in ACE2-expressing proximal tubular epithelial cells in diabetic kidney disease (searchable at hb.flatironinstitute.org/covid-kidney) that were linked to viral entry, immune activation, endomembrane reorganization, and RNA processing. The diabetic kidney disease ACE2-positive proximal tubular epithelial cell module overlapped with expression patterns seen in SARS-CoV-2-infected cells. Similar cellular programs were seen in ACE2-positive proximal tubular epithelial cells obtained from urine samples of 13 hospitalized patients with COVID-19, suggesting a consistent ACE2-coregulated proximal tubular epithelial cell expression program that may interact with the SARS-CoV-2 infection processes. Thus SARS-CoV-2 receptor networks can seed further research into risk stratification and therapeutic strategies for COVID-19-related kidney damage. |Adult[MESH] |Aged[MESH] |Angiotensin Receptor Antagonists/pharmacology/therapeutic use[MESH] |Angiotensin-Converting Enzyme 2/*metabolism[MESH] |Angiotensin-Converting Enzyme Inhibitors/pharmacology/therapeutic use[MESH] |COVID-19/complications/*metabolism/virology[MESH] |Case-Control Studies[MESH] |Diabetic Nephropathies/drug therapy/*metabolism[MESH] |Female[MESH] |Gene Expression Profiling[MESH] |Gene Regulatory Networks[MESH] |Host-Pathogen Interactions[MESH] |Humans[MESH] |Kidney Tubules, Proximal/drug effects/*metabolism[MESH] |Male[MESH] |Middle Aged[MESH]SARS-CoV-2 receptor networks in diabetic and COVID-19-associated kidne(epmc).pdf DeepDyve Pubget Overpricing