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10.1016/j.ejphar.2020.173620 http://scihub22266oqcxt.onion/10.1016/j.ejphar.2020.173620 33038418!7539138!33038418     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33038418&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Eur+J+Pharmacol 2021 ; 890 (ä): 173620 Nephropedia Template TP {{tp|p=33038418|t=2021. Targeting pivotal inflammatory pathways in COVID-19: A mechanistic review |pdf=|usr=}}{{33038418}} gab.com Text Targeting pivotal inflammatory pathways in COVID-19: A mechanistic review JO: Eur J Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=33038418 #FOAvip As an emerging global health crisis, coronavirus disease 2019 (COVID-19) has been labeled a worldwide pandemic. Growing evidence is revealing further pathophysiological mechanisms of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Amongst these dysregulated pathways inflammation seems to play a more critical role toward COVID-19 complications. In the present study, precise inflammatory pathways triggered by SARS-CoV-2, along with potential therapeutic candidates have been discussed. Prevailing evidence has indicated a close correlation of inflammatory cascades with severity, pathological progression, and organ damages in COVID-19 patients. From the mechanistic point of view, interleukin-6, interleukin-1beta receptor, interferon-gamma, tumor necrosis factor-alpha receptor, toll-like receptor, receptor tyrosine kinases, growth factor receptor, Janus kinase/signal transducers and transcription pathway, mammalian target of rapamycin, cytokine storm and macrophage activation have shown to play critical roles in COVID-19 complications. So, there is an urgent need to provide novel mechanistic-based anti-inflammatory agents. This review highlights inflammatory signaling pathways of SARS-CoV-2. Several therapeutic targets and treatment strategies have also been provided in an attempt to tackle COVID-19 complications. Twit Text FOAVip Targeting pivotal inflammatory pathways in COVID-19: A mechanistic review ????Eur J Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=33038418 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33038418 #FOAvip English Wikipedia <ref>{{Cite pmid|33038418}}</ref> Targeting pivotal inflammatory pathways in COVID-19: A mechanistic review #MMPMID33038418 Yarmohammadi A; Yarmohammadi M; Fakhri S; Khan H Eur J Pharmacol 2021[Jan]; 890 (ä): 173620 PMID33038418show ga As an emerging global health crisis, coronavirus disease 2019 (COVID-19) has been labeled a worldwide pandemic. Growing evidence is revealing further pathophysiological mechanisms of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Amongst these dysregulated pathways inflammation seems to play a more critical role toward COVID-19 complications. In the present study, precise inflammatory pathways triggered by SARS-CoV-2, along with potential therapeutic candidates have been discussed. Prevailing evidence has indicated a close correlation of inflammatory cascades with severity, pathological progression, and organ damages in COVID-19 patients. From the mechanistic point of view, interleukin-6, interleukin-1beta receptor, interferon-gamma, tumor necrosis factor-alpha receptor, toll-like receptor, receptor tyrosine kinases, growth factor receptor, Janus kinase/signal transducers and transcription pathway, mammalian target of rapamycin, cytokine storm and macrophage activation have shown to play critical roles in COVID-19 complications. So, there is an urgent need to provide novel mechanistic-based anti-inflammatory agents. This review highlights inflammatory signaling pathways of SARS-CoV-2. Several therapeutic targets and treatment strategies have also been provided in an attempt to tackle COVID-19 complications. |*COVID-19 Drug Treatment[MESH] |*SARS-CoV-2[MESH] |Anti-Inflammatory Agents/*therapeutic use[MESH] |COVID-19/immunology[MESH] |Humans[MESH]Targeting pivotal inflammatory pathways in COVID-19: A mechanistic rev(epmc).pdf DeepDyve Pubget Overpricing