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Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Br+J+Haematol 2020 ; 191 (3): 390-393 Nephropedia Template TP
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A left shift in the oxyhaemoglobin dissociation curve in patients with severe coronavirus disease 2019 (COVID-19) #MMPMID33037620
Vogel DJ; Formenti F; Retter AJ; Vasques F; Camporota L
Br J Haematol 2020[Nov]; 191 (3): 390-393 PMID33037620show ga
Critically ill patients with coronavirus disease 2019 (COVID-19) present with hypoxaemia and are mechanically ventilated to support gas exchange. We performed a retrospective, observational study of blood gas analyses (n = 3518) obtained from patients with COVID-19 to investigate changes in haemoglobin oxygen (Hb-O(2) ) affinity. Calculated oxygen tension at half-saturation (p(50) ) was on average (+/-SD) 3.3 (3.13) mmHg lower than the normal p(50) value (23.4 vs. 26.7 mmHg; P < 0.0001). Compared to an unmatched historic control of patients with other causes of severe respiratory failure, patients with COVID-19 had a significantly higher Hb-O(2) affinity (mean [SD] p(50) 23.4 [3.13] vs. 24.6 [5.4] mmHg; P < 0.0001). We hypothesise that, due to the long disease process, acclimatisation to hypoxaemia could play a role.