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10.1111/bjh.17128

http://scihub22266oqcxt.onion/10.1111/bjh.17128
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33037620!7675360!33037620
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suck abstract from ncbi


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pmid33037620      Br+J+Haematol 2020 ; 191 (3): 390-393
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  • A left shift in the oxyhaemoglobin dissociation curve in patients with severe coronavirus disease 2019 (COVID-19) #MMPMID33037620
  • Vogel DJ; Formenti F; Retter AJ; Vasques F; Camporota L
  • Br J Haematol 2020[Nov]; 191 (3): 390-393 PMID33037620show ga
  • Critically ill patients with coronavirus disease 2019 (COVID-19) present with hypoxaemia and are mechanically ventilated to support gas exchange. We performed a retrospective, observational study of blood gas analyses (n = 3518) obtained from patients with COVID-19 to investigate changes in haemoglobin oxygen (Hb-O(2) ) affinity. Calculated oxygen tension at half-saturation (p(50) ) was on average (+/-SD) 3.3 (3.13) mmHg lower than the normal p(50) value (23.4 vs. 26.7 mmHg; P < 0.0001). Compared to an unmatched historic control of patients with other causes of severe respiratory failure, patients with COVID-19 had a significantly higher Hb-O(2) affinity (mean [SD] p(50) 23.4 [3.13] vs. 24.6 [5.4] mmHg; P < 0.0001). We hypothesise that, due to the long disease process, acclimatisation to hypoxaemia could play a role.
  • |*Betacoronavirus[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |COVID-19[MESH]
  • |Carbon Dioxide/blood[MESH]
  • |Coronavirus Infections/*blood[MESH]
  • |Dyspnea/blood/etiology[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Hydrogen-Ion Concentration[MESH]
  • |Hypoxia/blood/etiology[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Models, Cardiovascular[MESH]
  • |Oxygen/blood[MESH]
  • |Oxyhemoglobins/*metabolism[MESH]
  • |Pandemics[MESH]
  • |Partial Pressure[MESH]
  • |Pneumonia, Viral/*blood[MESH]
  • |Retrospective Studies[MESH]


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