Relation of D-dimer levels of COVID-19 patients with diabetes mellitus #MMPMID33035824
Mishra Y; Pathak BK; Mohakuda SS; Tilak TVSVGK; Sen S; P H; Singh R; Singh AR
Diabetes Metab Syndr 2020[Nov]; 14 (6): 1927-1930 PMID33035824show ga
BACKGROUND AND AIMS: Diabetes is a frequent comorbidity in patients with Severe COVID-19 infection associated with a worse prognosis. Hypercoagulability with elevation in D-dimer levels has been demonstrated in patients with COVID-19. This study aims to study D-dimer levels in people with diabetes compared to those without diabetes among patients with COVID-19 infection. METHODS: In this observational study 98 moderate and severely ill patients with COVID-19 infection were included at a dedicated COVID hospital. The study group was divided into patients with diabetes and without diabetes. Peak D-dimer was measured in both the groups and compared using appropriate statistical tests. RESULTS: In our study peak D-dimer levels were 1509 +/- 2420 ng/mL (Mean +/- SD) in people with diabetes and 515 +/- 624 ng/mL (Mean +/- SD) in patients without diabetes. Patients with diabetes had higher D-dimer levels which were statistically significant. CONCLUSIONS: This study shows COVID-19 patients with diabetes had significantly higher D-dimer levels. Therefore, it is possible that COVID-19 infection with diabetes is more likely to cause hypercoagulable state with a worse prognosis. However clinical implications of these findings will need to be seen in further studies.
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Diabetes+Metab+Syndr 2020 ; 14 (6): 1927-1930
