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10.1016/j.cell.2020.08.049 http://scihub22266oqcxt.onion/10.1016/j.cell.2020.08.049 33035451!7572828!33035451     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell 2020 ; 183 (2): 474-489.e17 Nephropedia Template TP {{tp|p=33035451|t=2020. Lactate Elicits ER-Mitochondrial Mg(2+) Dynamics to Integrate Cellular Metabolism |pdf=|usr=}}{{33035451}} gab.com Text Lactate Elicits ER-Mitochondrial Mg(2+) Dynamics to Integrate Cellular Metabolism JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=33035451 #FOAvip Mg(2+) is the most abundant divalent cation in metazoans and an essential cofactor for ATP, nucleic acids, and countless metabolic enzymes. To understand how the spatio-temporal dynamics of intracellular Mg(2+) ((i)Mg(2+)) are integrated into cellular signaling, we implemented a comprehensive screen to discover regulators of (i)Mg(2+) dynamics. Lactate emerged as an activator of rapid release of Mg(2+) from endoplasmic reticulum (ER) stores, which facilitates mitochondrial Mg(2+) ((m)Mg(2+)) uptake in multiple cell types. We demonstrate that this process is remarkably temperature sensitive and mediated through intracellular but not extracellular signals. The ER-mitochondrial Mg(2+) dynamics is selectively stimulated by L-lactate. Further, we show that lactate-mediated (m)Mg(2+) entry is facilitated by Mrs2, and point mutations in the intermembrane space loop limits (m)Mg(2+) uptake. Intriguingly, suppression of (m)Mg(2+) surge alleviates inflammation-induced multi-organ failure. Together, these findings reveal that lactate mobilizes (i)Mg(2+) and links the (m)Mg(2+) transport machinery with major metabolic feedback circuits and mitochondrial bioenergetics. Twit Text FOAVip Lactate Elicits ER-Mitochondrial Mg(2+) Dynamics to Integrate Cellular Metabolism ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=33035451 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33035451 #FOAvip English Wikipedia <ref>{{Cite pmid|33035451}}</ref> Lactate Elicits ER-Mitochondrial Mg(2+) Dynamics to Integrate Cellular Metabolism #MMPMID33035451 Daw CC; Ramachandran K; Enslow BT; Maity S; Bursic B; Novello MJ; Rubannelsonkumar CS; Mashal AH; Ravichandran J; Bakewell TM; Wang W; Li K; Madaris TR; Shannon CE; Norton L; Kandala S; Caplan J; Srikantan S; Stathopulos PB; Reeves WB; Madesh M Cell 2020[Oct]; 183 (2): 474-489.e17 PMID33035451show ga Mg(2+) is the most abundant divalent cation in metazoans and an essential cofactor for ATP, nucleic acids, and countless metabolic enzymes. To understand how the spatio-temporal dynamics of intracellular Mg(2+) ((i)Mg(2+)) are integrated into cellular signaling, we implemented a comprehensive screen to discover regulators of (i)Mg(2+) dynamics. Lactate emerged as an activator of rapid release of Mg(2+) from endoplasmic reticulum (ER) stores, which facilitates mitochondrial Mg(2+) ((m)Mg(2+)) uptake in multiple cell types. We demonstrate that this process is remarkably temperature sensitive and mediated through intracellular but not extracellular signals. The ER-mitochondrial Mg(2+) dynamics is selectively stimulated by L-lactate. Further, we show that lactate-mediated (m)Mg(2+) entry is facilitated by Mrs2, and point mutations in the intermembrane space loop limits (m)Mg(2+) uptake. Intriguingly, suppression of (m)Mg(2+) surge alleviates inflammation-induced multi-organ failure. Together, these findings reveal that lactate mobilizes (i)Mg(2+) and links the (m)Mg(2+) transport machinery with major metabolic feedback circuits and mitochondrial bioenergetics. |Animals[MESH] |COS Cells[MESH] |Calcium Signaling/physiology[MESH] |Calcium/metabolism[MESH] |Chlorocebus aethiops[MESH] |Endoplasmic Reticulum/*metabolism/physiology[MESH] |Female[MESH] |HeLa Cells[MESH] |Hep G2 Cells[MESH] |Humans[MESH] |Lactic Acid/*metabolism[MESH] |Magnesium/*metabolism[MESH] |Male[MESH] |Mice, Inbred C57BL[MESH] |Mice, Knockout[MESH]Lactate Elicits ER-Mitochondrial Mg(2+) Dynamics to Integrate Cellular(epmc).pdf DeepDyve Pubget Overpricing