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10.1088/1361-6579/abb1fb

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suck abstract from ncbi


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pmid33035199      Physiol+Meas 2020 ; 41 (9): 095011
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  • Monitoring lung impedance changes during long-term ventilator-induced lung injury ventilation using electrical impedance tomography #MMPMID33035199
  • Hahn G; Niewenhuys J; Just A; Tonetti T; Behnemann T; Rapetti F; Collino F; Vasques F; Maiolo G; Romitti F; Gattinoni L; Quintel M; Moerer O
  • Physiol Meas 2020[Oct]; 41 (9): 095011 PMID33035199show ga
  • OBJECTIVE: The target of this methodological evaluation was the feasibility of long-term monitoring of changes in lung conditions by time-difference electrical impedance tomography (tdEIT). In contrast to ventilation monitoring by tdEIT, the monitoring of end-expiratory (EELIC) or end-inspiratory (EILIC) lung impedance change always requires a reference measurement. APPROACH: To determine the stability of the used Pulmovista 500((R)) EIT system, as a prerequisite it was initially secured on a resistive phantom for 50 h. By comparing the slopes of EELIC for the whole lung area up to 48 h from 36 pigs ventilated at six positive end-expiratory pressure (PEEP) levels from 0 to 18 cmH(2)O we found a good agreement (range of r (2) = 0.93-1.0) between absolute EIT (aEIT) and tdEIT values. This justified the usage of tdEIT with its superior local resolution compared to aEIT for long-term determination of EELIC. MAIN RESULTS: The EELIC was between -0.07 Omegam day(-1) at PEEP 4 and -1.04 Omegam day(-1) at PEEP 18 cmH(2)O. The complex local time pattern for EELIC was roughly quantified by the new parameter, centre of end-expiratory change (CoEEC), in equivalence to the established centre of ventilation (CoV). The ventrally located mean of the CoV was fairly constant in the range of 42%-46% of thorax diameter; however, on the contrary, the CoEEC shifted from about 40% to about 75% in the dorsal direction for PEEP levels of 14 and 18 cmH(2)O. SIGNIFICANCE: The observed shifts started earlier for higher PEEP levels. Changes of EELI could be precisely monitored over a period of 48 h by tdEIT on pigs.
  • |*Monitoring, Physiologic[MESH]
  • |*Tomography[MESH]
  • |Animals[MESH]
  • |Electric Impedance[MESH]
  • |Exhalation[MESH]
  • |Swine[MESH]
  • |Time Factors[MESH]


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