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10.1126/sciimmunol.abe5511 http://scihub22266oqcxt.onion/10.1126/sciimmunol.abe5511 33033173!8050884!33033173     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33033173&cmd=llinks): Failed to open stream: HTTP request failed! 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Persistence of serum and saliva antibody responses to SARS-CoV-2 spike antigens in COVID-19 patients |pdf=|usr=}}{{33033173}} gab.com Text Persistence of serum and saliva antibody responses to SARS-CoV-2 spike antigens in COVID-19 patients JO: Sci Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33033173 #FOAvip While the antibody response to SARS-CoV-2 has been extensively studied in blood, relatively little is known about the antibody response in saliva and its relationship to systemic antibody levels. Here, we profiled by enzyme-linked immunosorbent assays (ELISAs) IgG, IgA and IgM responses to the SARS-CoV-2 spike protein (full length trimer) and its receptor-binding domain (RBD) in serum and saliva of acute and convalescent patients with laboratory-diagnosed COVID-19 ranging from 3-115 days post-symptom onset (PSO), compared to negative controls. Anti-SARS-CoV-2 antibody responses were readily detected in serum and saliva, with peak IgG levels attained by 16-30 days PSO. Longitudinal analysis revealed that anti-SARS-CoV-2 IgA and IgM antibodies rapidly decayed, while IgG antibodies remained relatively stable up to 105 days PSO in both biofluids. Lastly, IgG, IgM and to a lesser extent IgA responses to spike and RBD in the serum positively correlated with matched saliva samples. This study confirms that serum and saliva IgG antibodies to SARS-CoV-2 are maintained in the majority of COVID-19 patients for at least 3 months PSO. IgG responses in saliva may serve as a surrogate measure of systemic immunity to SARS-CoV-2 based on their correlation with serum IgG responses. Twit Text FOAVip Persistence of serum and saliva antibody responses to SARS-CoV-2 spike antigens in COVID-19 patients ????Sci Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33033173 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33033173 #FOAvip English Wikipedia <ref>{{Cite pmid|33033173}}</ref> Persistence of serum and saliva antibody responses to SARS-CoV-2 spike antigens in COVID-19 patients #MMPMID33033173 Isho B; Abe KT; Zuo M; Jamal AJ; Rathod B; Wang JH; Li Z; Chao G; Rojas OL; Bang YM; Pu A; Christie-Holmes N; Gervais C; Ceccarelli D; Samavarchi-Tehrani P; Guvenc F; Budylowski P; Li A; Paterson A; Yue FY; Marin LM; Caldwell L; Wrana JL; Colwill K; Sicheri F; Mubareka S; Gray-Owen SD; Drews SJ; Siqueira WL; Barrios-Rodiles M; Ostrowski M; Rini JM; Durocher Y; McGeer AJ; Gommerman JL; Gingras AC Sci Immunol 2020[Oct]; 5 (52): ä PMID33033173show ga While the antibody response to SARS-CoV-2 has been extensively studied in blood, relatively little is known about the antibody response in saliva and its relationship to systemic antibody levels. Here, we profiled by enzyme-linked immunosorbent assays (ELISAs) IgG, IgA and IgM responses to the SARS-CoV-2 spike protein (full length trimer) and its receptor-binding domain (RBD) in serum and saliva of acute and convalescent patients with laboratory-diagnosed COVID-19 ranging from 3-115 days post-symptom onset (PSO), compared to negative controls. Anti-SARS-CoV-2 antibody responses were readily detected in serum and saliva, with peak IgG levels attained by 16-30 days PSO. Longitudinal analysis revealed that anti-SARS-CoV-2 IgA and IgM antibodies rapidly decayed, while IgG antibodies remained relatively stable up to 105 days PSO in both biofluids. Lastly, IgG, IgM and to a lesser extent IgA responses to spike and RBD in the serum positively correlated with matched saliva samples. This study confirms that serum and saliva IgG antibodies to SARS-CoV-2 are maintained in the majority of COVID-19 patients for at least 3 months PSO. IgG responses in saliva may serve as a surrogate measure of systemic immunity to SARS-CoV-2 based on their correlation with serum IgG responses. |Adult[MESH] |Antibodies, Viral/*blood[MESH] |Antigens, Viral/*immunology[MESH] |Betacoronavirus/*immunology[MESH] |COVID-19[MESH] |Coronavirus Infections/*immunology/virology[MESH] |Cross-Sectional Studies[MESH] |Enzyme-Linked Immunosorbent Assay[MESH] |Female[MESH] |Humans[MESH] |Immunoglobulin A/blood/immunology[MESH] |Immunoglobulin G/blood/immunology[MESH] |Immunoglobulin M/blood/immunology[MESH] |Longitudinal Studies[MESH] |Male[MESH] |Middle Aged[MESH] |Pandemics[MESH] |Pneumonia, Viral/*immunology/virology[MESH] |SARS-CoV-2[MESH] |Saliva/*immunology[MESH]Persistence of serum and saliva antibody responses to SARS-CoV-2 spike(epmc).pdf DeepDyve Pubget Overpricing