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10.1124/jpet.120.000170 http://scihub22266oqcxt.onion/10.1124/jpet.120.000170 33033170!7718727!33033170     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Pharmacol+Exp+Ther 2020 ; 375 (3): 498-509 Nephropedia Template TP {{tp|p=33033170|t=2020. The Role of Smoking and Nicotine in the Transmission and Pathogenesis of COVID-19 |pdf=|usr=}}{{33033170}} gab.com Text The Role of Smoking and Nicotine in the Transmission and Pathogenesis of COVID-19 JO: J Pharmacol Exp Ther http://www.kidney.de/pget.php?&tw=1&pmid=33033170 #FOAvip Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 virus, is turning out to be one of the most devastating global pandemics in the history of humankind. There is a shortage of effective therapeutic strategies or preventative vaccines for this disease to date. A rigorous investigation is needed for identifying and developing more effective therapeutic strategies for COVID-19. Angiotensin-converting enzyme 2 (ACE2), a crucial factor in COVID-19 pathogenesis, has been identified as a potential target for COVID-19 treatment. Smoking and vaping are potential risk factors for COVID-19 that are also shown to upregulate ACE2 expression. In this review, we have discussed the pathobiology of COVID-19 in the lungs and brain and the role of ACE2 in the transmission and pathobiology of this disease. Furthermore, we have shown possible interactions between nicotine/smoking and ACE2 in the lungs and brain, which could aggravate the transmission and pathobiology of COVID-19, resulting in a poor disease outcome. SIGNIFICANCE STATEMENT: This review addresses the present global pandemic of coronavirus disease 2019 (COVID-19) with respect to its pathobiology in the lungs and brain. It focuses on the potential negative impact of tobacco and nicotine exposure on the outcomes of this disease by interaction with the angiotensin-converting enzyme 2 receptor. It adds to the time-sensitive and critically important growing knowledge about the risk factors, transmission, pathobiology, and prognosis of COVID-19. Twit Text FOAVip The Role of Smoking and Nicotine in the Transmission and Pathogenesis of COVID-19 ????J Pharmacol Exp Ther http://www.kidney.de/pget.php?&tw=1&pmid=33033170 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33033170 #FOAvip English Wikipedia <ref>{{Cite pmid|33033170}}</ref> The Role of Smoking and Nicotine in the Transmission and Pathogenesis of COVID-19 #MMPMID33033170 Sifat AE; Nozohouri S; Villalba H; Vaidya B; Abbruscato TJ J Pharmacol Exp Ther 2020[Dec]; 375 (3): 498-509 PMID33033170show ga Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 virus, is turning out to be one of the most devastating global pandemics in the history of humankind. There is a shortage of effective therapeutic strategies or preventative vaccines for this disease to date. A rigorous investigation is needed for identifying and developing more effective therapeutic strategies for COVID-19. Angiotensin-converting enzyme 2 (ACE2), a crucial factor in COVID-19 pathogenesis, has been identified as a potential target for COVID-19 treatment. Smoking and vaping are potential risk factors for COVID-19 that are also shown to upregulate ACE2 expression. In this review, we have discussed the pathobiology of COVID-19 in the lungs and brain and the role of ACE2 in the transmission and pathobiology of this disease. Furthermore, we have shown possible interactions between nicotine/smoking and ACE2 in the lungs and brain, which could aggravate the transmission and pathobiology of COVID-19, resulting in a poor disease outcome. SIGNIFICANCE STATEMENT: This review addresses the present global pandemic of coronavirus disease 2019 (COVID-19) with respect to its pathobiology in the lungs and brain. It focuses on the potential negative impact of tobacco and nicotine exposure on the outcomes of this disease by interaction with the angiotensin-converting enzyme 2 receptor. It adds to the time-sensitive and critically important growing knowledge about the risk factors, transmission, pathobiology, and prognosis of COVID-19. |Angiotensin-Converting Enzyme 2/metabolism[MESH] |Animals[MESH] |Brain/drug effects/metabolism/virology[MESH] |COVID-19/*epidemiology/etiology/transmission[MESH] |Humans[MESH] |Lung/drug effects/metabolism/virology[MESH] |Nicotine/metabolism/toxicity[MESH] |SARS-CoV-2/pathogenicity[MESH]The Role of Smoking and Nicotine in the Transmission and Pathogenesis (epmc).pdf DeepDyve Pubget Overpricing