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10.1183/13993003.02708-2020 http://scihub22266oqcxt.onion/10.1183/13993003.02708-2020 33033152!7758538!33033152     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Eur+Respir+J 2020 ; 56 (6): ä Nephropedia Template TP {{tp|p=33033152|t=2020. Cellular senescence: friend or foe to respiratory viral infections?|pdf=|usr=}}{{33033152}} gab.com Text Cellular senescence: friend or foe to respiratory viral infections JO: Eur Respir J http://www.kidney.de/pget.php?&tw=1&pmid=33033152 #FOAvip Cellular senescence permanently arrests the replication of various cell types and contributes to age-associated diseases. In particular, cellular senescence may enhance chronic lung diseases including COPD and idiopathic pulmonary fibrosis. However, the role cellular senescence plays in the pathophysiology of acute inflammatory diseases, especially viral infections, is less well understood. There is evidence that cellular senescence prevents viral replication by increasing antiviral cytokines, but other evidence shows that senescence may enhance viral replication by downregulating antiviral signalling. Furthermore, cellular senescence leads to the secretion of inflammatory mediators, which may either promote host defence or exacerbate immune pathology during viral infections. In this Perspective article, we summarise how senescence contributes to physiology and disease, the role of senescence in chronic lung diseases, and how senescence impacts acute respiratory viral infections. Finally, we develop a potential framework for how senescence may contribute, both positively and negatively, to the pathophysiology of viral respiratory infections, including severe acute respiratory syndrome due to the coronavirus SARS-CoV-2. Twit Text FOAVip Cellular senescence: friend or foe to respiratory viral infections ????Eur Respir J http://www.kidney.de/pget.php?&tw=1&pmid=33033152 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33033152 #FOAvip English Wikipedia <ref>{{Cite pmid|33033152}}</ref> Cellular senescence: friend or foe to respiratory viral infections? #MMPMID33033152 Kelley WJ; Zemans RL; Goldstein DR Eur Respir J 2020[Dec]; 56 (6): ä PMID33033152show ga Cellular senescence permanently arrests the replication of various cell types and contributes to age-associated diseases. In particular, cellular senescence may enhance chronic lung diseases including COPD and idiopathic pulmonary fibrosis. However, the role cellular senescence plays in the pathophysiology of acute inflammatory diseases, especially viral infections, is less well understood. There is evidence that cellular senescence prevents viral replication by increasing antiviral cytokines, but other evidence shows that senescence may enhance viral replication by downregulating antiviral signalling. Furthermore, cellular senescence leads to the secretion of inflammatory mediators, which may either promote host defence or exacerbate immune pathology during viral infections. In this Perspective article, we summarise how senescence contributes to physiology and disease, the role of senescence in chronic lung diseases, and how senescence impacts acute respiratory viral infections. Finally, we develop a potential framework for how senescence may contribute, both positively and negatively, to the pathophysiology of viral respiratory infections, including severe acute respiratory syndrome due to the coronavirus SARS-CoV-2. |*Cellular Senescence[MESH] |Humans[MESH] |Lung/pathology[MESH] |Respiratory Tract Infections/*pathology/*virology[MESH]Cellular senescence: friend or foe to respiratory viral infections?(epmc).pdf DeepDyve Pubget Overpricing