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10.1016/j.mam.2020.100918 http://scihub22266oqcxt.onion/10.1016/j.mam.2020.100918 33032828!7534736!33032828     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mol+Aspects+Med 2021 ; 77 (ä): 100918 Nephropedia Template TP {{tp|p=33032828|t=2021. Metabolic adaptations of cells at the vascular-immune interface during atherosclerosis |pdf=|usr=}}{{33032828}} gab.com Text Metabolic adaptations of cells at the vascular-immune interface during atherosclerosis JO: Mol Aspects Med http://www.kidney.de/pget.php?&tw=1&pmid=33032828 #FOAvip Metabolic reprogramming is a physiological cellular adaptation to intracellular and extracellular stimuli that couples to cell polarization and function in multiple cellular subsets. Pathological conditions associated to nutrients overload, such as dyslipidaemia, may disturb cellular metabolic homeostasis and, in turn, affect cellular response and activation, thus contributing to disease progression. At the vascular/immune interface, the site of atherosclerotic plaque development, many of these changes occur. Here, an intimate interaction between endothelial cells (ECs), vascular smooth muscle cells (VSMCs) and immune cells, mainly monocytes/macrophages and lymphocytes, dictates physiological versus pathological response. Furthermore, atherogenic stimuli trigger metabolic adaptations both at systemic and cellular level that affect the EC layer barrier integrity, VSMC proliferation and migration, monocyte infiltration, macrophage polarization, lymphocyte T and B activation. Rewiring cellular metabolism by repurposing "metabolic drugs" might represent a pharmacological approach to modulate cell activation at the vascular immune interface thus contributing to control the immunometabolic response in the context of cardiovascular diseases. Twit Text FOAVip Metabolic adaptations of cells at the vascular-immune interface during atherosclerosis ????Mol Aspects Med http://www.kidney.de/pget.php?&tw=1&pmid=33032828 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33032828 #FOAvip English Wikipedia <ref>{{Cite pmid|33032828}}</ref> Metabolic adaptations of cells at the vascular-immune interface during atherosclerosis #MMPMID33032828 Bonacina F; Da Dalt L; Catapano AL; Norata GD Mol Aspects Med 2021[Feb]; 77 (ä): 100918 PMID33032828show ga Metabolic reprogramming is a physiological cellular adaptation to intracellular and extracellular stimuli that couples to cell polarization and function in multiple cellular subsets. Pathological conditions associated to nutrients overload, such as dyslipidaemia, may disturb cellular metabolic homeostasis and, in turn, affect cellular response and activation, thus contributing to disease progression. At the vascular/immune interface, the site of atherosclerotic plaque development, many of these changes occur. Here, an intimate interaction between endothelial cells (ECs), vascular smooth muscle cells (VSMCs) and immune cells, mainly monocytes/macrophages and lymphocytes, dictates physiological versus pathological response. Furthermore, atherogenic stimuli trigger metabolic adaptations both at systemic and cellular level that affect the EC layer barrier integrity, VSMC proliferation and migration, monocyte infiltration, macrophage polarization, lymphocyte T and B activation. Rewiring cellular metabolism by repurposing "metabolic drugs" might represent a pharmacological approach to modulate cell activation at the vascular immune interface thus contributing to control the immunometabolic response in the context of cardiovascular diseases. |*Atherosclerosis[MESH] |*Plaque, Atherosclerotic[MESH] |Endothelial Cells[MESH] |Humans[MESH] |Muscle, Smooth, Vascular[MESH]Metabolic adaptations of cells at the vascular-immune interface during(epmc).pdf DeepDyve Pubget Overpricing