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10.1016/j.cmi.2020.09.057 http://scihub22266oqcxt.onion/10.1016/j.cmi.2020.09.057 33031947!7534827!33031947     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33031947&cmd=llinks): Failed to open stream: HTTP request failed! 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Accuracy of a nucleocapsid protein antigen rapid test in the diagnosis of SARS-CoV-2 infection |pdf=|usr=}}{{33031947}} gab.com Text Accuracy of a nucleocapsid protein antigen rapid test in the diagnosis of SARS-CoV-2 infection JO: Clin Microbiol Infect http://www.kidney.de/pget.php?&tw=1&pmid=33031947 #FOAvip OBJECTIVES: Rapid, reliable and easy-to-implement diagnostics that can be adapted in early severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) diagnosis are critical to combat the epidemic. SARS-CoV-2 nucleocapsid protein (NP) is an ideal target for viral antigen-based detection. A rapid and convenient method was developed based on fluorescence immunochromatographic (FIC) assay to detect the SARS-CoV-2 NP antigen. However, the accuracy of this diagnostic method needs to be examined. METHODS: This prospective study was carried out between 10 and 15 February 2020 in seven hospitals in Wuhan and one hospital in Chongqing, China. Participants with clinically suspected SARS-CoV-2 infection were enrolled. NP antigen testing by FIC assay and nucleic acid (NA) testing by real-time reverse transcriptase PCR (RT-PCR) were performed simultaneously in a blinded manner with the same nasopharyngeal swab sample. The diagnostic accuracy of NP antigen testing was calculated by taking NA testing of RT-PCR as the reference standard, in which samples with a cycle threshold (C(t)) value of </=40 were interpreted as positive for SARS-CoV-2. RESULTS: A total of 253 participants were enrolled; two participants were excluded from the analyses because of invalid NP testing results. Of 251 participants (99.2%) included in the diagnostic accuracy analysis, 201 (80.1%) had a C(t) value of </=40. With C(t) value 40 as the cutoff of NA testing, the sensitivity, specificity and percentage agreement of the FIC assay was 75.6% (95% confidence interval, 69.0-81.3), 100% (95% confidence interval, 91.1-100) and 80.5% (95% confidence interval, 75.1-84.9) respectively. CONCLUSIONS: With RT-PCR assay as the reference standard, NP antigen testing by FIC assay shows high specificity and relatively high sensitivity in SARS-CoV-2 diagnosis in the early phase of infection. Twit Text FOAVip Accuracy of a nucleocapsid protein antigen rapid test in the diagnosis of SARS-CoV-2 infection ????Clin Microbiol Infect http://www.kidney.de/pget.php?&tw=1&pmid=33031947 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33031947 #FOAvip English Wikipedia <ref>{{Cite pmid|33031947}}</ref> Accuracy of a nucleocapsid protein antigen rapid test in the diagnosis of SARS-CoV-2 infection #MMPMID33031947 Diao B; Wen K; Zhang J; Chen J; Han C; Chen Y; Wang S; Deng G; Zhou H; Wu Y Clin Microbiol Infect 2021[Feb]; 27 (2): 289.e1-289.e4 PMID33031947show ga OBJECTIVES: Rapid, reliable and easy-to-implement diagnostics that can be adapted in early severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) diagnosis are critical to combat the epidemic. SARS-CoV-2 nucleocapsid protein (NP) is an ideal target for viral antigen-based detection. A rapid and convenient method was developed based on fluorescence immunochromatographic (FIC) assay to detect the SARS-CoV-2 NP antigen. However, the accuracy of this diagnostic method needs to be examined. METHODS: This prospective study was carried out between 10 and 15 February 2020 in seven hospitals in Wuhan and one hospital in Chongqing, China. Participants with clinically suspected SARS-CoV-2 infection were enrolled. NP antigen testing by FIC assay and nucleic acid (NA) testing by real-time reverse transcriptase PCR (RT-PCR) were performed simultaneously in a blinded manner with the same nasopharyngeal swab sample. The diagnostic accuracy of NP antigen testing was calculated by taking NA testing of RT-PCR as the reference standard, in which samples with a cycle threshold (C(t)) value of |Adolescent[MESH] |Adult[MESH] |Aged[MESH] |Antigens, Viral/*analysis[MESH] |COVID-19 Testing/*methods/standards[MESH] |COVID-19/*diagnosis[MESH] |Coronavirus Nucleocapsid Proteins/*analysis[MESH] |Female[MESH] |Humans[MESH] |Immunoassay[MESH] |Male[MESH] |Middle Aged[MESH] |Nasopharynx/virology[MESH] |Phosphoproteins/analysis[MESH] |Prospective Studies[MESH] |RNA, Viral/genetics[MESH] |SARS-CoV-2/genetics/immunology/*isolation & purification[MESH] |Sensitivity and Specificity[MESH]Accuracy of a nucleocapsid protein antigen rapid test in the diagnosis(epmc).pdf DeepDyve Pubget Overpricing