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10.1155/2020/4932572 http://scihub22266oqcxt.onion/10.1155/2020/4932572 33029165!7532411!33029165     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Evid+Based+Complement+Alternat+Med 2020 ; 2020 (ä): 4932572 Nephropedia Template TP {{tp|p=33029165|t=2020. Investigating Potential Inhibitory Effect of Uncaria tomentosa (Cat s Claw) against the Main Protease 3CL(pro) of SARS-CoV-2 by Molecular Modeling |pdf=|usr=}}{{33029165}} gab.com Text Investigating Potential Inhibitory Effect of Uncaria tomentosa (Cat s Claw) against the Main Protease 3CL(pro) of SARS-CoV-2 by Molecular Modeling JO: Evid Based Complement Alternat Med http://www.kidney.de/pget.php?&tw=1&pmid=33029165 #FOAvip COVID-19 is a disease caused by severe acute respiratory syndrome coronavirus 2. Presently, there is no effective treatment for COVID-19. As part of the worldwide efforts to find efficient therapies and preventions, it has been reported the crystalline structure of the SARS-CoV-2 main protease M(pro) (also called 3CL(pro)) bound to a synthetic inhibitor, which represents a major druggable target. The druggability of M(pro) could be used for discovering drugs to treat COVID-19. A multilevel computational study was carried out to evaluate the potential antiviral properties of the components of the medicinal herb Uncaria tomentosa (Cat's claw), focusing on the inhibition of M(pro). The in silico approach starts with protein-ligand docking of 26 Cat's claw key components, followed by ligand pathway calculations, molecular dynamics simulations, and MM-GBSA calculation of the free energy of binding for the best docked candidates. The structural bioinformatics approaches led to identification of three bioactive compounds of Uncaria tomentosa (speciophylline, cadambine, and proanthocyanidin B2) with potential therapeutic effects by strong interaction with 3CL(pro). Additionally, in silico drug-likeness indices for these components were calculated and showed good predicted therapeutic profiles of these phytochemicals. Our findings suggest the potential effectiveness of Cat's claw as complementary and/or alternative medicine for COVID-19 treatment. Twit Text FOAVip Investigating Potential Inhibitory Effect of Uncaria tomentosa (Cat s Claw) against the Main Protease 3CL(pro) of SARS-CoV-2 by Molecular Modeling ????Evid Based Complement Alternat Med http://www.kidney.de/pget.php?&tw=1&pmid=33029165 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33029165 #FOAvip English Wikipedia <ref>{{Cite pmid|33029165}}</ref> Investigating Potential Inhibitory Effect of Uncaria tomentosa (Cat s Claw) against the Main Protease 3CL(pro) of SARS-CoV-2 by Molecular Modeling #MMPMID33029165 Yepes-Perez AF; Herrera-Calderon O; Sanchez-Aparicio JE; Tiessler-Sala L; Marechal JD; Cardona-G W Evid Based Complement Alternat Med 2020[]; 2020 (ä): 4932572 PMID33029165show ga COVID-19 is a disease caused by severe acute respiratory syndrome coronavirus 2. Presently, there is no effective treatment for COVID-19. As part of the worldwide efforts to find efficient therapies and preventions, it has been reported the crystalline structure of the SARS-CoV-2 main protease M(pro) (also called 3CL(pro)) bound to a synthetic inhibitor, which represents a major druggable target. The druggability of M(pro) could be used for discovering drugs to treat COVID-19. A multilevel computational study was carried out to evaluate the potential antiviral properties of the components of the medicinal herb Uncaria tomentosa (Cat's claw), focusing on the inhibition of M(pro). The in silico approach starts with protein-ligand docking of 26 Cat's claw key components, followed by ligand pathway calculations, molecular dynamics simulations, and MM-GBSA calculation of the free energy of binding for the best docked candidates. The structural bioinformatics approaches led to identification of three bioactive compounds of Uncaria tomentosa (speciophylline, cadambine, and proanthocyanidin B2) with potential therapeutic effects by strong interaction with 3CL(pro). Additionally, in silico drug-likeness indices for these components were calculated and showed good predicted therapeutic profiles of these phytochemicals. Our findings suggest the potential effectiveness of Cat's claw as complementary and/or alternative medicine for COVID-19 treatment. äInvestigating Potential Inhibitory Effect of Uncaria tomentosa (Cat s (epmc).pdf DeepDyve Pubget Overpricing