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10.1038/s41564-020-00802-x http://scihub22266oqcxt.onion/10.1038/s41564-020-00802-x 33028965!ä!33028965 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Microbiol 2020 ; 5 (11): 1439-1448 Nephropedia Template TP {{tp|p=33028965|t=2020. Metallodrug ranitidine bismuth citrate suppresses SARS-CoV-2 replication and relieves virus-associated pneumonia in Syrian hamsters |pdf=|usr=}}{{33028965}} gab.com Text Metallodrug ranitidine bismuth citrate suppresses SARS-CoV-2 replication and relieves virus-associated pneumonia in Syrian hamsters JO: Nat Microbiol http://www.kidney.de/pget.php?&tw=1&pmid=33028965 #FOAvip SARS-CoV-2 is causing a pandemic of COVID-19, with high infectivity and significant mortality(1). Currently, therapeutic options for COVID-19 are limited. Historically, metal compounds have found use as antimicrobial agents, but their antiviral activities have rarely been explored. Here, we test a set of metallodrugs and related compounds, and identify ranitidine bismuth citrate, a commonly used drug for the treatment of Helicobacter pylori infection, as a potent anti-SARS-CoV-2 agent, both in vitro and in vivo. Ranitidine bismuth citrate exhibited low cytotoxicity and protected SARS-CoV-2-infected cells with a high selectivity index of 975. Importantly, ranitidine bismuth citrate suppressed SARS-CoV-2 replication, leading to decreased viral loads in both upper and lower respiratory tracts, and relieved virus-associated pneumonia in a golden Syrian hamster model. In vitro studies showed that ranitidine bismuth citrate and its related compounds exhibited inhibition towards both the ATPase (IC(50) = 0.69 microM) and DNA-unwinding (IC(50) = 0.70 microM) activities of the SARS-CoV-2 helicase via an irreversible displacement of zinc(II) ions from the enzyme by bismuth(III) ions. Our findings highlight viral helicase as a druggable target and the clinical potential of bismuth(III) drugs or other metallodrugs for the treatment of SARS-CoV-2 infection. Twit Text FOAVip Metallodrug ranitidine bismuth citrate suppresses SARS-CoV-2 replication and relieves virus-associated pneumonia in Syrian hamsters ????Nat Microbiol http://www.kidney.de/pget.php?&tw=1&pmid=33028965 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33028965 #FOAvip English Wikipedia <ref>{{Cite pmid|33028965}}</ref> Metallodrug ranitidine bismuth citrate suppresses SARS-CoV-2 replication and relieves virus-associated pneumonia in Syrian hamsters #MMPMID33028965 Yuan S; Wang R; Chan JF; Zhang AJ; Cheng T; Chik KK; Ye ZW; Wang S; Lee AC; Jin L; Li H; Jin DY; Yuen KY; Sun H Nat Microbiol 2020[Nov]; 5 (11): 1439-1448 PMID33028965show ga SARS-CoV-2 is causing a pandemic of COVID-19, with high infectivity and significant mortality(1). Currently, therapeutic options for COVID-19 are limited. Historically, metal compounds have found use as antimicrobial agents, but their antiviral activities have rarely been explored. Here, we test a set of metallodrugs and related compounds, and identify ranitidine bismuth citrate, a commonly used drug for the treatment of Helicobacter pylori infection, as a potent anti-SARS-CoV-2 agent, both in vitro and in vivo. Ranitidine bismuth citrate exhibited low cytotoxicity and protected SARS-CoV-2-infected cells with a high selectivity index of 975. Importantly, ranitidine bismuth citrate suppressed SARS-CoV-2 replication, leading to decreased viral loads in both upper and lower respiratory tracts, and relieved virus-associated pneumonia in a golden Syrian hamster model. In vitro studies showed that ranitidine bismuth citrate and its related compounds exhibited inhibition towards both the ATPase (IC(50) = 0.69 microM) and DNA-unwinding (IC(50) = 0.70 microM) activities of the SARS-CoV-2 helicase via an irreversible displacement of zinc(II) ions from the enzyme by bismuth(III) ions. Our findings highlight viral helicase as a druggable target and the clinical potential of bismuth(III) drugs or other metallodrugs for the treatment of SARS-CoV-2 infection. |Animals[MESH] |Antiviral Agents/*pharmacology[MESH] |Betacoronavirus/*drug effects/physiology[MESH] |Bismuth/*pharmacology[MESH] |COVID-19[MESH] |COVID-19 Drug Treatment[MESH] |Chemokines/metabolism[MESH] |Chlorocebus aethiops[MESH] |Coronavirus Infections/drug therapy/*virology[MESH] |Cytokines/metabolism[MESH] |Disease Models, Animal[MESH] |HEK293 Cells[MESH] |Humans[MESH] |Lung/pathology/virology[MESH] |Mesocricetus[MESH] |Pandemics[MESH] |Pneumonia, Viral/drug therapy/*virology[MESH] |RNA Helicases/metabolism[MESH] |Ranitidine/*analogs & derivatives/pharmacology[MESH] |SARS-CoV-2[MESH] |Vero Cells[MESH] |Viral Load[MESH]Metallodrug ranitidine bismuth citrate suppresses SARS-CoV-2 replicati(epmc).pdf DeepDyve Pubget Overpricing