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10.1038/s41579-020-00443-1 http://scihub22266oqcxt.onion/10.1038/s41579-020-00443-1 33024310!7537969!33024310     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Rev+Microbiol 2021 ; 19 (2): 123-132 Nephropedia Template TP {{tp|p=33024310|t=2021. Proximate and ultimate causes of the bactericidal action of antibiotics |pdf=|usr=}}{{33024310}} gab.com Text Proximate and ultimate causes of the bactericidal action of antibiotics JO: Nat Rev Microbiol http://www.kidney.de/pget.php?&tw=1&pmid=33024310 #FOAvip During the past 85 years of antibiotic use, we have learned a great deal about how these 'miracle' drugs work. We know the molecular structures and interactions of these drugs and their targets and the effects on the structure, physiology and replication of bacteria. Collectively, we know a great deal about these proximate mechanisms of action for virtually all antibiotics in current use. What we do not know is the ultimate mechanism of action; that is, how these drugs irreversibly terminate the 'individuality' of bacterial cells by removing barriers to the external world (cell envelopes) or by destroying their genetic identity (DNA). Antibiotics have many different 'mechanisms of action' that converge to irreversible lethal effects. In this Perspective, we consider what our knowledge of the proximate mechanisms of action of antibiotics and the pharmacodynamics of their interaction with bacteria tell us about the ultimate mechanisms by which these antibiotics kill bacteria. Twit Text FOAVip Proximate and ultimate causes of the bactericidal action of antibiotics ????Nat Rev Microbiol http://www.kidney.de/pget.php?&tw=1&pmid=33024310 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33024310 #FOAvip English Wikipedia <ref>{{Cite pmid|33024310}}</ref> Proximate and ultimate causes of the bactericidal action of antibiotics #MMPMID33024310 Baquero F; Levin BR Nat Rev Microbiol 2021[Feb]; 19 (2): 123-132 PMID33024310show ga During the past 85 years of antibiotic use, we have learned a great deal about how these 'miracle' drugs work. We know the molecular structures and interactions of these drugs and their targets and the effects on the structure, physiology and replication of bacteria. Collectively, we know a great deal about these proximate mechanisms of action for virtually all antibiotics in current use. What we do not know is the ultimate mechanism of action; that is, how these drugs irreversibly terminate the 'individuality' of bacterial cells by removing barriers to the external world (cell envelopes) or by destroying their genetic identity (DNA). Antibiotics have many different 'mechanisms of action' that converge to irreversible lethal effects. In this Perspective, we consider what our knowledge of the proximate mechanisms of action of antibiotics and the pharmacodynamics of their interaction with bacteria tell us about the ultimate mechanisms by which these antibiotics kill bacteria. |Anti-Bacterial Agents/*pharmacology[MESH] |Bacteria/*drug effects[MESH] |Bacterial Infections/drug therapy[MESH] |Cell Membrane/*drug effects[MESH] |Microbial Sensitivity Tests[MESH]Proximate and ultimate causes of the bactericidal action of antibiotic(epmc).pdf DeepDyve Pubget Overpricing