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10.1038/s41577-020-00460-4 http://scihub22266oqcxt.onion/10.1038/s41577-020-00460-4 33024281!7537578!33024281     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Rev+Immunol 2020 ; 20 (11): 709-713 Nephropedia Template TP {{tp|p=33024281|t=2020. Cross-reactive memory T cells and herd immunity to SARS-CoV-2 |pdf=|usr=}}{{33024281}} gab.com Text Cross-reactive memory T cells and herd immunity to SARS-CoV-2 JO: Nat Rev Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33024281 #FOAvip Immunity is a multifaceted phenomenon. For T cell-mediated memory responses to SARS-CoV-2, it is relevant to consider their impact both on COVID-19 disease severity and on viral spread in a population. Here, we reflect on the immunological and epidemiological aspects and implications of pre-existing cross-reactive immune memory to SARS-CoV-2, which largely originates from previous exposure to circulating common cold coronaviruses. We propose four immunological scenarios for the impact of cross-reactive CD4(+) memory T cells on COVID-19 severity and viral transmission. For each scenario, we discuss its implications for the dynamics of herd immunity and on projections of the global impact of SARS-CoV-2 on the human population, and assess its plausibility. In sum, we argue that key potential impacts of cross-reactive T cell memory are already incorporated into epidemiological models based on data of transmission dynamics, particularly with regard to their implications for herd immunity. The implications of immunological processes on other aspects of SARS-CoV-2 epidemiology are worthy of future study. Twit Text FOAVip Cross-reactive memory T cells and herd immunity to SARS-CoV-2 ????Nat Rev Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33024281 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33024281 #FOAvip English Wikipedia <ref>{{Cite pmid|33024281}}</ref> Cross-reactive memory T cells and herd immunity to SARS-CoV-2 #MMPMID33024281 Lipsitch M; Grad YH; Sette A; Crotty S Nat Rev Immunol 2020[Nov]; 20 (11): 709-713 PMID33024281show ga Immunity is a multifaceted phenomenon. For T cell-mediated memory responses to SARS-CoV-2, it is relevant to consider their impact both on COVID-19 disease severity and on viral spread in a population. Here, we reflect on the immunological and epidemiological aspects and implications of pre-existing cross-reactive immune memory to SARS-CoV-2, which largely originates from previous exposure to circulating common cold coronaviruses. We propose four immunological scenarios for the impact of cross-reactive CD4(+) memory T cells on COVID-19 severity and viral transmission. For each scenario, we discuss its implications for the dynamics of herd immunity and on projections of the global impact of SARS-CoV-2 on the human population, and assess its plausibility. In sum, we argue that key potential impacts of cross-reactive T cell memory are already incorporated into epidemiological models based on data of transmission dynamics, particularly with regard to their implications for herd immunity. The implications of immunological processes on other aspects of SARS-CoV-2 epidemiology are worthy of future study. |Adaptive Immunity/drug effects[MESH] |Antibodies, Viral/*biosynthesis[MESH] |Betacoronavirus/drug effects/*immunology/pathogenicity[MESH] |CD4-Positive T-Lymphocytes/drug effects/immunology/virology[MESH] |COVID-19[MESH] |COVID-19 Vaccines[MESH] |Coronaviridae Infections/epidemiology/immunology/*prevention & control/virology[MESH] |Coronaviridae/drug effects/immunology[MESH] |Coronavirus Infections/epidemiology/immunology/*prevention & control/virology[MESH] |Cross Reactions[MESH] |Humans[MESH] |Immunity, Herd/drug effects[MESH] |Immunologic Memory[MESH] |Pandemics/*prevention & control[MESH] |Pneumonia, Viral/epidemiology/immunology/*prevention & control/virology[MESH] |Rhinovirus/drug effects/immunology[MESH] |SARS-CoV-2[MESH]Cross-reactive memory T cells and herd immunity to SARS-CoV-2 (epmc).pdf DeepDyve Pubget Overpricing