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10.1038/s41598-020-73554-7

http://scihub22266oqcxt.onion/10.1038/s41598-020-73554-7
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suck abstract from ncbi


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pmid33024144      Sci+Rep 2020 ; 10 (1): 16602
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  • Molecular epidemiology of the first wave of severe acute respiratory syndrome coronavirus 2 infection in Thailand in 2020 #MMPMID33024144
  • Puenpa J; Suwannakarn K; Chansaenroj J; Nilyanimit P; Yorsaeng R; Auphimai C; Kitphati R; Mungaomklang A; Kongklieng A; Chirathaworn C; Wanlapakorn N; Poovorawan Y
  • Sci Rep 2020[Oct]; 10 (1): 16602 PMID33024144show ga
  • The coronavirus disease 2019 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a major global concern. Several SARS-CoV-2 gene mutations have been reported. In the current study associations between SARS-CoV-2 gene variation and exposure history during the first wave of the outbreak in Thailand between January and May 2020 were investigated. Forty samples were collected at different time points during the outbreak, and parts of the SARS-CoV-2 genome sequence were used to assess genomic variation patterns. The phylogenetics of the 40 samples were clustered into L, GH, GR, O and T types. T types were predominant in Bangkok during the first local outbreak centered at a boxing stadium and entertainment venues in March 2020. Imported cases were infected with various types, including L, GH, GR and O. In southern Thailand introductions of different genotypes were identified at different times. No clinical parameters were significantly associated with differences in genotype. The results indicated local transmission (type T, Spike protein (A829T)) and imported cases (types L, GH, GR and O) during the first wave in Thailand. Genetic and epidemiological data may contribute to national policy formulation, transmission tracking and the implementation of measures to control viral spread.
  • |Base Sequence[MESH]
  • |Betacoronavirus/*genetics[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/*epidemiology/*transmission/virology[MESH]
  • |Genome, Viral/*genetics[MESH]
  • |Genotype[MESH]
  • |Humans[MESH]
  • |Molecular Epidemiology[MESH]
  • |Mutation[MESH]
  • |Pandemics[MESH]
  • |Phylogeny[MESH]
  • |Pneumonia, Viral/*epidemiology/*transmission/virology[MESH]
  • |Polymerase Chain Reaction/methods[MESH]
  • |Polymorphism, Single Nucleotide[MESH]
  • |SARS-CoV-2[MESH]


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