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10.1128/JCM.02338-20

http://scihub22266oqcxt.onion/10.1128/JCM.02338-20
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33023911!7771450!33023911
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suck abstract from ncbi


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pmid33023911      J+Clin+Microbiol 2020 ; 59 (1): ä
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  • Clinical Evaluation of BD Veritor SARS-CoV-2 Point-of-Care Test Performance Compared to PCR-Based Testing and versus the Sofia 2 SARS Antigen Point-of-Care Test #MMPMID33023911
  • Young S; Taylor SN; Cammarata CL; Varnado KG; Roger-Dalbert C; Montano A; Griego-Fullbright C; Burgard C; Fernandez C; Eckert K; Andrews JC; Ren H; Allen J; Ackerman R; Cooper CK
  • J Clin Microbiol 2020[Dec]; 59 (1): ä PMID33023911show ga
  • The clinical performance of the BD Veritor System for Rapid Detection of SARS-CoV-2 nucleocapsid antigen (Veritor), a chromatographic immunoassay used for SARS-CoV-2 point-of-care testing, was evaluated using nasal specimens from individuals with COVID-19 symptoms. Two studies were completed to determine clinical performance. In the first study, nasal specimens and either nasopharyngeal or oropharyngeal specimens from 251 participants with COVID-19 symptoms (/=18 years of age) were utilized to compare Veritor with the Lyra SARS-CoV-2 PCR assay (Lyra). In the second study, nasal specimens from 361 participants with COVID-19 symptoms (/=18 years of age) were utilized to compare performance of Veritor to that of the Sofia 2 SARS Antigen FIA test (Sofia 2). The positive, negative, and overall percent agreement (PPA, NPA, and OPA, respectively) were the primary outcomes. In study 1, the PPA for Veritor, compared to Lyra, ranged from 81.8 to 87.5% across the 0 to 1 and 0 to 6 DSO ranges. In study 2, Veritor had PPA, NPA, and OPA values of 97.4, 98.1, and 98.1%, respectively, with Sofia 2. Discordant analysis showed one Lyra positive missed by Veritor and five Lyra positives missed by Sofia 2; one Veritor positive result was negative by Lyra. Veritor met FDA emergency use authorization (EUA) acceptance criteria for SARS-CoV-2 antigen testing for the 0 to 5 and 0 to 6 DSO ranges (PPA values of 83.9% and 82.4%, respectively). Veritor and Sofia 2 showed a high degree of agreement for SARS-CoV-2 detection. The Veritor test allows for more rapid COVID-19 testing utilizing easy-to-collect nasal swabs but demonstrated <100% PPA compared to PCR.
  • |Adult[MESH]
  • |Antigens, Viral/*analysis[MESH]
  • |COVID-19 Testing/*methods[MESH]
  • |COVID-19/*diagnosis[MESH]
  • |Coronavirus Nucleocapsid Proteins/*analysis[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Immunoassay/methods[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Nasopharynx/virology[MESH]
  • |Oropharynx/virology[MESH]
  • |Point-of-Care Testing[MESH]
  • |Polymerase Chain Reaction/methods[MESH]
  • |SARS-CoV-2/genetics/immunology[MESH]
  • |Sensitivity and Specificity[MESH]


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