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10.1016/j.it.2020.09.008

http://scihub22266oqcxt.onion/10.1016/j.it.2020.09.008
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33023856!7510552!33023856
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suck abstract from ncbi

pmid33023856      Trends+Immunol 2020 ; 41 (11): 965-967
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  • The Complement C5a-C5aR1 GPCR Axis in COVID-19 Therapeutics #MMPMID33023856
  • Woodruff TM; Shukla AK
  • Trends Immunol 2020[Nov]; 41 (11): 965-967 PMID33023856show ga
  • The current pandemic of coronavirus disease (COVID-19) caused by SARS-CoV-2 is a significant global health challenge. A recent study by Carvelli and colleagues now demonstrates the involvement of complement C5a and its receptor C5aR1 in disease progression and suggests that blockade of the C5a-C5aR1 axis may represent a potential therapeutic strategy against COVID-19.
  • |Animals[MESH]
  • |Antibodies, Monoclonal/immunology/pharmacology[MESH]
  • |Betacoronavirus/drug effects/*immunology/physiology[MESH]
  • |COVID-19[MESH]
  • |Complement C5a/*immunology/metabolism[MESH]
  • |Coronavirus Infections/*immunology/therapy/virology[MESH]
  • |Disease Models, Animal[MESH]
  • |Humans[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*immunology/therapy/virology[MESH]
  • |Receptor, Anaphylatoxin C5a/*immunology/metabolism[MESH]
  • |Receptors, G-Protein-Coupled/immunology/metabolism[MESH]
  • |SARS-CoV-2[MESH]


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