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10.3390/molecules25194531 http://scihub22266oqcxt.onion/10.3390/molecules25194531 33022923!7582934!33022923     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Molecules 2020 ; 25 (19): ä Nephropedia Template TP {{tp|p=33022923|t=2020. Synthesis of New Imidazopyridine Nucleoside Derivatives Designed as Maribavir Analogues |pdf=|usr=}}{{33022923}} gab.com Text Synthesis of New Imidazopyridine Nucleoside Derivatives Designed as Maribavir Analogues JO: Molecules http://www.kidney.de/pget.php?&tw=1&pmid=33022923 #FOAvip The strong inhibition of Human Cytomegalovirus (HCMV) replication by benzimidazole nucleosides, like Triciribine and Maribavir, has prompted us to expand the structure-activity relationships of the benzimidazole series, using as a central core the imidazo[4,5-b]pyridine scaffold. We have thus synthesized a number of novel amino substituted imidazopyridine nucleoside derivatives, which can be considered as 4-(or 7)-aza-d-isosters of Maribavir and have evaluated their potential antiviral activity. The target compounds were synthesized upon glycosylation of suitably substituted 2-aminoimidazopyridines, which were prepared in six steps starting from 2-amino-6-chloropyridine. Even if the new compounds possessed only a slight structural modification when compared to the original drug, they were not endowed with interesting antiviral activity. Even so, three derivatives showed promising cytotoxic potential. Twit Text FOAVip Synthesis of New Imidazopyridine Nucleoside Derivatives Designed as Maribavir Analogues ????Molecules http://www.kidney.de/pget.php?&tw=1&pmid=33022923 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33022923 #FOAvip English Wikipedia <ref>{{Cite pmid|33022923}}</ref> Synthesis of New Imidazopyridine Nucleoside Derivatives Designed as Maribavir Analogues #MMPMID33022923 Papadakis G; Gerasi M; Snoeck R; Marakos P; Andrei G; Lougiakis N; Pouli N Molecules 2020[Oct]; 25 (19): ä PMID33022923show ga The strong inhibition of Human Cytomegalovirus (HCMV) replication by benzimidazole nucleosides, like Triciribine and Maribavir, has prompted us to expand the structure-activity relationships of the benzimidazole series, using as a central core the imidazo[4,5-b]pyridine scaffold. We have thus synthesized a number of novel amino substituted imidazopyridine nucleoside derivatives, which can be considered as 4-(or 7)-aza-d-isosters of Maribavir and have evaluated their potential antiviral activity. The target compounds were synthesized upon glycosylation of suitably substituted 2-aminoimidazopyridines, which were prepared in six steps starting from 2-amino-6-chloropyridine. Even if the new compounds possessed only a slight structural modification when compared to the original drug, they were not endowed with interesting antiviral activity. Even so, three derivatives showed promising cytotoxic potential. |Antiviral Agents/chemistry/pharmacology[MESH] |Benzimidazoles/*chemistry/pharmacology[MESH] |Cell Line[MESH] |Cytomegalovirus/drug effects[MESH] |Glycosylation[MESH] |Humans[MESH] |Imidazoles/*chemical synthesis/chemistry[MESH] |Nucleosides/*chemical synthesis/chemistry[MESH] |Pyridines/*chemical synthesis/chemistry[MESH]Synthesis of New Imidazopyridine Nucleoside Derivatives Designed as Ma(epmc).pdf DeepDyve Pubget Overpricing