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10.1016/j.acra.2020.09.003

http://scihub22266oqcxt.onion/10.1016/j.acra.2020.09.003
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33020043!7505583!33020043
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suck abstract from ncbi


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pmid33020043      Acad+Radiol 2021 ; 28 (12): 1654-1661
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  • Correlation Between Low-Dose Chest Computed Tomography and RT-PCR Results for the Diagnosis of COVID-19: A Report of 27,824 Cases in Tehran, Iran #MMPMID33020043
  • Zali A; Sohrabi MR; Mahdavi A; Khalili N; Taheri MS; Maher A; Sadoughi M; Zarghi A; Ziai SA; Shabestari AA; Bakhshayeshkaram M; Haghighatkhah H; Salevatipour B; Abrishami A; Raoufi M; Dehghan P; Bagheri AK; Khoshnoud RJ; Hanani K
  • Acad Radiol 2021[Dec]; 28 (12): 1654-1661 PMID33020043show ga
  • RATIONALE AND OBJECTIVES: Real-time polymerase chain reaction (RT-PCR) remains the gold standard for confirmation of Coronavirus Disease 2019 (COVID-19) despite having many disadvantages. Here, we investigated the diagnostic performance of chest computed tomography (CT) as an alternative to RT-PCR in patients with clinical suspicion of COVID-19 infection. METHODS: In this descriptive cross-sectional study, 27,824 patients with clinical suspicion of COVID-19 infection who underwent unenhanced low-dose chest CT from 20 February, 2020 to 21 May, 2020 were evaluated. Patients were recruited from seven specifically designated hospitals for patients with COVID-19 infection affiliated to Shahid Beheshti University of Medical Sciences. In each hospital, images were interpreted by two independent radiologists. CT findings were considered as positive/negative for COVID-19 infection based on RSNA diagnostic criteria. Then, the correlation between the number of daily positive chest CT scans and number of daily PCR-confirmed cases and COVID-19-related deaths in Tehran province during this three-month period was assessed. The trends of admission rate and patients with positive CT scans were also evaluated. RESULTS: A strong positive correlation between the numbers of daily positive CT scans and daily PCR-confirmed COVID-19 cases (r?=?0.913, p < 0.001) was observed. Furthermore, in hospitals located in regions with a lower socioeconomic status, the admission rate and number of positive cases within this three-month period was higher as compared to other hospitals. CONCLUSION: Low-dose chest CT is a safe, rapid and reliable alternative to RT-PCR for the diagnosis of COVID-19 in high-prevalence regions. In addition, our study provides further evidence for considering patients' socioeconomic status as an important risk factor for COVID-19.
  • |*COVID-19[MESH]
  • |Cross-Sectional Studies[MESH]
  • |Humans[MESH]
  • |Iran/epidemiology[MESH]
  • |Reverse Transcriptase Polymerase Chain Reaction[MESH]
  • |SARS-CoV-2[MESH]
  • |Sensitivity and Specificity[MESH]


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